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Conformational mAb as a tool for integrin ligand discovery.
Njus BH, Chigaev A, Waller A, Wlodek D, Ostopovici-Halip L, Ursu O, Wang W, Oprea TI, Bologa CG, Sklar LA. Njus BH, et al. Among authors: chigaev a. Assay Drug Dev Technol. 2009 Oct;7(5):507-15. doi: 10.1089/adt.2009.0203. Assay Drug Dev Technol. 2009. PMID: 19754304 Free PMC article.
Alpha4beta1 integrin affinity changes govern cell adhesion.
Chigaev A, Zwartz G, Graves SW, Dwyer DC, Tsuji H, Foutz TD, Edwards BS, Prossnitz ER, Larson RS, Sklar LA. Chigaev A, et al. J Biol Chem. 2003 Oct 3;278(40):38174-82. doi: 10.1074/jbc.M210472200. Epub 2003 Jul 3. J Biol Chem. 2003. PMID: 12844491 Free article.
Different mechanisms, including changes in the number of interacting molecules due to the alteration of the receptor topology or changes in the affinity of the individual bonds, have been proposed to explain the nature of these fast changes in avidity. Recently, we described a …
Different mechanisms, including changes in the number of interacting molecules due to the alteration of the receptor topology or changes in …
47 results