Rutherford TJ - Search Results

1

Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53.

Wong TS, Rajagopalan S, Freund SM, Rutherford TJ, Andreeva A, Townsley FM, Petrovich M, Fersht AR. Wong TS, et al. Among authors: rutherford tj. Nucleic Acids Res. 2009 Nov;37(20):6765-83. doi: 10.1093/nar/gkp750. Epub 2009 Sep 15. Nucleic Acids Res. 2009. PMID: 19755502 Free PMC article.

2

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.

Wells M, Tidow H, Rutherford TJ, Markwick P, Jensen MR, Mylonas E, Svergun DI, Blackledge M, Fersht AR. Wells M, et al. Among authors: rutherford tj. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5762-7. doi: 10.1073/pnas.0801353105. Epub 2008 Apr 7. Proc Natl Acad Sci U S A. 2008. PMID: 18391200 Free PMC article.

3

Members of the S100 family bind p53 in two distinct ways.

Fernandez-Fernandez MR, Rutherford TJ, Fersht AR. Fernandez-Fernandez MR, et al. Among authors: rutherford tj. Protein Sci. 2008 Oct;17(10):1663-70. doi: 10.1110/ps.035527.108. Epub 2008 Aug 11. Protein Sci. 2008. PMID: 18694925 Free PMC article.

4

Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.

Rajagopalan S, Andreeva A, Rutherford TJ, Fersht AR. Rajagopalan S, et al. Among authors: rutherford tj. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8587-92. doi: 10.1073/pnas.1003689107. Epub 2010 Apr 26. Proc Natl Acad Sci U S A. 2010. PMID: 20421506 Free PMC article.

5

Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53.

van Dieck J, Teufel DP, Jaulent AM, Fernandez-Fernandez MR, Rutherford TJ, Wyslouch-Cieszynska A, Fersht AR. van Dieck J, et al. Among authors: rutherford tj. J Mol Biol. 2009 Dec 18;394(5):922-30. doi: 10.1016/j.jmb.2009.10.002. Epub 2009 Oct 9. J Mol Biol. 2009. PMID: 19819244

6

Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.

Friedler A, Veprintsev DB, Rutherford T, von Glos KI, Fersht AR. Friedler A, et al. J Biol Chem. 2005 Mar 4;280(9):8051-9. doi: 10.1074/jbc.M411176200. Epub 2004 Dec 20. J Biol Chem. 2005. PMID: 15611070 Free article.

7

Solution structure of p53 core domain: structural basis for its instability.

Cañadillas JM, Tidow H, Freund SM, Rutherford TJ, Ang HC, Fersht AR. Cañadillas JM, et al. Among authors: rutherford tj. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2109-14. doi: 10.1073/pnas.0510941103. Epub 2006 Feb 6. Proc Natl Acad Sci U S A. 2006. PMID: 16461916 Free PMC article.

8

Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold.

Tidow H, Andreeva A, Rutherford TJ, Fersht AR. Tidow H, et al. Among authors: rutherford tj. J Mol Biol. 2007 Aug 24;371(4):948-58. doi: 10.1016/j.jmb.2007.05.024. Epub 2007 May 13. J Mol Biol. 2007. PMID: 17594908

9

The role of the turn in beta-hairpin formation during WW domain folding.

Sharpe T, Jonsson AL, Rutherford TJ, Daggett V, Fersht AR. Sharpe T, et al. Among authors: rutherford tj. Protein Sci. 2007 Oct;16(10):2233-9. doi: 10.1110/ps.073004907. Epub 2007 Aug 31. Protein Sci. 2007. PMID: 17766370 Free PMC article.

10

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.

Boeckler FM, Joerger AC, Jaggi G, Rutherford TJ, Veprintsev DB, Fersht AR. Boeckler FM, et al. Among authors: rutherford tj. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5. doi: 10.1073/pnas.0805326105. Epub 2008 Jul 23. Proc Natl Acad Sci U S A. 2008. PMID: 18650397 Free PMC article.

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