Ryan A - Search Results

1

Targeting vascular endothelial growth factor receptor-1 and -3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines.

Morelli MP, Brown AM, Pitts TM, Tentler JJ, Ciardiello F, Ryan A, Jürgensmeier JM, Eckhardt SG. Morelli MP, et al. Among authors: ryan a. Mol Cancer Ther. 2009 Sep;8(9):2546-58. doi: 10.1158/1535-7163.MCT-09-0380. Epub 2009 Sep 15. Mol Cancer Ther. 2009. PMID: 19755510 Free PMC article.

2

Antitumor and antiangiogenic activity of cediranib in a preclinical model of renal cell carcinoma.

Medinger M, Esser N, Zirrgiebel U, Ryan A, Jürgensmeier JM, Drevs J. Medinger M, et al. Among authors: ryan a. Anticancer Res. 2009 Dec;29(12):5065-76. Anticancer Res. 2009. PMID: 20044618 Free article.

3

Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers.

Smith NR, Baker D, James NH, Ratcliffe K, Jenkins M, Ashton SE, Sproat G, Swann R, Gray N, Ryan A, Jürgensmeier JM, Womack C. Smith NR, et al. Among authors: ryan a. Clin Cancer Res. 2010 Jul 15;16(14):3548-61. doi: 10.1158/1078-0432.CCR-09-2797. Epub 2010 Jul 6. Clin Cancer Res. 2010. PMID: 20606037

4

Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells.

Bianco R, Rosa R, Damiano V, Daniele G, Gelardi T, Garofalo S, Tarallo V, De Falco S, Melisi D, Benelli R, Albini A, Ryan A, Ciardiello F, Tortora G. Bianco R, et al. Among authors: ryan a. Clin Cancer Res. 2008 Aug 15;14(16):5069-80. doi: 10.1158/1078-0432.CCR-07-4905. Epub 2008 Aug 11. Clin Cancer Res. 2008. PMID: 18694994

5

Combined MEK and VEGFR inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis.

Takahashi O, Komaki R, Smith PD, Jürgensmeier JM, Ryan A, Bekele BN, Wistuba II, Jacoby JJ, Korshunova MV, Biernacka A, Erez B, Hosho K, Herbst RS, O'Reilly MS. Takahashi O, et al. Among authors: ryan a. Clin Cancer Res. 2012 Mar 15;18(6):1641-54. doi: 10.1158/1078-0432.CCR-11-2324. Epub 2012 Jan 24. Clin Cancer Res. 2012. PMID: 22275507 Free PMC article.

6

Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small-cell lung cancer.

Shibuya K, Komaki R, Shintani T, Itasaka S, Ryan A, Jürgensmeier JM, Milas L, Ang K, Herbst RS, O'Reilly MS. Shibuya K, et al. Among authors: ryan a. Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1534-43. doi: 10.1016/j.ijrobp.2007.07.2350. Epub 2007 Sep 24. Int J Radiat Oncol Biol Phys. 2007. PMID: 17889445 Free PMC article.

7

ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor with additional activity against epidermal growth factor receptor tyrosine kinase, inhibits orthotopic growth and angiogenesis of gastric cancer.

McCarty MF, Wey J, Stoeltzing O, Liu W, Fan F, Bucana C, Mansfield PF, Ryan AJ, Ellis LM. McCarty MF, et al. Mol Cancer Ther. 2004 Sep;3(9):1041-8. Mol Cancer Ther. 2004. PMID: 15367698

8

Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade.

Wu W, Onn A, Isobe T, Itasaka S, Langley RR, Shitani T, Shibuya K, Komaki R, Ryan AJ, Fidler IJ, Herbst RS, O'Reilly MS. Wu W, et al. Among authors: ryan aj. Mol Cancer Ther. 2007 Feb;6(2):471-83. doi: 10.1158/1535-7163.MCT-06-0416. Mol Cancer Ther. 2007. PMID: 17308046

9

ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases.

Carlomagno F, Vitagliano D, Guida T, Ciardiello F, Tortora G, Vecchio G, Ryan AJ, Fontanini G, Fusco A, Santoro M. Carlomagno F, et al. Among authors: ryan aj. Cancer Res. 2002 Dec 15;62(24):7284-90. Cancer Res. 2002. PMID: 12499271

10

The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells.

Vitagliano D, De Falco V, Tamburrino A, Coluzzi S, Troncone G, Chiappetta G, Ciardiello F, Tortora G, Fagin JA, Ryan AJ, Carlomagno F, Santoro M. Vitagliano D, et al. Among authors: ryan aj. Endocr Relat Cancer. 2010 Nov 30;18(1):1-11. doi: 10.1677/ERC-09-0292. Print 2011 Feb. Endocr Relat Cancer. 2010. PMID: 20943719

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