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Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane.
Suzuki T, Ishihara K, Migaki H, Matsuura W, Kohda A, Okumura K, Nagao M, Yamaguchi-Iwai Y, Kambe T. Suzuki T, et al. Among authors: ishihara k. J Biol Chem. 2005 Jan 7;280(1):637-43. doi: 10.1074/jbc.M411247200. Epub 2004 Nov 2. J Biol Chem. 2005. PMID: 15525635 Free article.
Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells.
Suzuki T, Ishihara K, Migaki H, Ishihara K, Nagao M, Yamaguchi-Iwai Y, Kambe T. Suzuki T, et al. Among authors: ishihara k. J Biol Chem. 2005 Sep 2;280(35):30956-62. doi: 10.1074/jbc.M506902200. Epub 2005 Jul 1. J Biol Chem. 2005. PMID: 15994300 Free article.
However, until recently little has been known about the molecules involved in the pathways required for supplying zinc to these enzymes. We showed recently (Suzuki, T., Ishihara, K., Migaki, H., Matsuura, W., Kohda, A., Okumura, K., Nagao, M., Yamaguchi-Iwai, …
However, until recently little has been known about the molecules involved in the pathways required for supplying zinc to these enzymes. We …
2,380 results