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146 results

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The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction.
Knust H, Achermann G, Ballard T, Buettelmann B, Gasser R, Fischer H, Hernandez MC, Knoflach F, Koblet A, Stadler H, Thomas AW, Trube G, Waldmeier P. Knust H, et al. Among authors: waldmeier p. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4. doi: 10.1016/j.bmcl.2009.08.053. Epub 2009 Aug 15. Bioorg Med Chem Lett. 2009. PMID: 19762240
Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity.
Alig L, Alsenz J, Andjelkovic M, Bendels S, Bénardeau A, Bleicher K, Bourson A, David-Pierson P, Guba W, Hildbrand S, Kube D, Lübbers T, Mayweg AV, Narquizian R, Neidhart W, Nettekoven M, Plancher JM, Rocha C, Rogers-Evans M, Röver S, Schneider G, Taylor S, Waldmeier P. Alig L, et al. Among authors: waldmeier p. J Med Chem. 2008 Apr 10;51(7):2115-27. doi: 10.1021/jm701487t. Epub 2008 Mar 13. J Med Chem. 2008. PMID: 18335976
6-Alkoxy-5-aryl-3-pyridinecarboxamides, a new series of bioavailable cannabinoid receptor type 1 (CB1) antagonists including peripherally selective compounds.
Röver S, Andjelkovic M, Bénardeau A, Chaput E, Guba W, Hebeisen P, Mohr S, Nettekoven M, Obst U, Richter WF, Ullmer C, Waldmeier P, Wright MB. Röver S, et al. Among authors: waldmeier p. J Med Chem. 2013 Dec 27;56(24):9874-96. doi: 10.1021/jm4010708. Epub 2013 Nov 20. J Med Chem. 2013. PMID: 24175572
Piperidine renin inhibitors: from leads to drug candidates.
Märki HP, Binggeli A, Bittner B, Bohner-Lang V, Breu V, Bur D, Coassolo PH, Clozel JP, D'Arcy A, Doebeli H, Fischli W, Funk CH, Foricher J, Giller T, Grüninger F, Guenzi A, Güller R, Hartung T, Hirth G, Jenny CH, Kansy M, Klinkhammer U, Lave T, Lohri B, Luft FC, Mervaala EM, Müller DN, Müller M, Montavon F, Oefner CH, Qiu C, Reichel A, Sanwald-Ducray P, Scalone M, Schleimer M, Schmid R, Stadler H, Treiber A, Valdenaire O, Vieira E, Waldmeier P, Wiegand-Chou R, Wilhelm M, Wostl W, Zell M, Zell R. Märki HP, et al. Among authors: waldmeier p. Farmaco. 2001 Jan-Feb;56(1-2):21-7. doi: 10.1016/s0014-827x(01)01004-7. Farmaco. 2001. PMID: 11347960
Strongyle faecal egg counts in Swiss horses: A retrospective analysis after the introduction of a selective treatment strategy.
Lüthin S, Zollinger A, Basso W, Bisig M, Caspari N, Eng V, Frey CF, Grimm F, Igel P, Lüthi S, Regli W, Roelfstra L, Rosskopf M, Steiner B, Stöckli M, Waidyasekera D, Waldmeier P, Schnyder M, Torgerson PR, Hertzberg H. Lüthin S, et al. Among authors: waldmeier p. Vet Parasitol. 2023 Nov;323:110027. doi: 10.1016/j.vetpar.2023.110027. Epub 2023 Sep 14. Vet Parasitol. 2023. PMID: 37837729
A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse.
Chopra V, Fox JH, Lieberman G, Dorsey K, Matson W, Waldmeier P, Housman DE, Kazantsev A, Young AB, Hersch S. Chopra V, et al. Among authors: waldmeier p. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16685-9. doi: 10.1073/pnas.0707842104. Epub 2007 Oct 9. Proc Natl Acad Sci U S A. 2007. PMID: 17925440 Free PMC article.
146 results