Tanaka J - Search Results

1

Metformin primarily decreases plasma glucose not by gluconeogenesis suppression but by activating glucose utilization in a non-obese type 2 diabetes Goto-Kakizaki rats.

Yoshida T, Okuno A, Tanaka J, Takahashi K, Nakashima R, Kanda S, Ogawa J, Hagisawa Y, Fujiwara T. Yoshida T, et al. Among authors: tanaka j. Eur J Pharmacol. 2009 Nov 25;623(1-3):141-7. doi: 10.1016/j.ejphar.2009.09.003. Epub 2009 Sep 15. Eur J Pharmacol. 2009. PMID: 19765581

2

Potent antidiabetic effects of rivoglitazone, a novel peroxisome proliferator-activated receptor-gamma agonist, in obese diabetic rodent models.

Kanda S, Nakashima R, Takahashi K, Tanaka J, Ogawa J, Ogata T, Yachi M, Araki K, Ohsumi J. Kanda S, et al. Among authors: tanaka j. J Pharmacol Sci. 2009 Oct;111(2):155-66. doi: 10.1254/jphs.09084fp. Epub 2009 Oct 6. J Pharmacol Sci. 2009. PMID: 19809220 Free article.

3

Discovery of potent and orally active tricyclic-based FBPase inhibitors.

Tsukada T, Kanno O, Yamane T, Tanaka J, Yoshida T, Okuno A, Shiiki T, Takahashi M, Nishi T. Tsukada T, et al. Among authors: tanaka j. Bioorg Med Chem. 2010 Jul 15;18(14):5346-51. doi: 10.1016/j.bmc.2010.05.041. Epub 2010 May 20. Bioorg Med Chem. 2010. PMID: 20542703

4

A prodrug approach towards the development of tricyclic-based FBPase inhibitors.

Tsukada T, Tamaki K, Tanaka J, Takagi T, Yoshida T, Okuno A, Shiiki T, Takahashi M, Nishi T. Tsukada T, et al. Among authors: tanaka j. Bioorg Med Chem Lett. 2010 May 1;20(9):2938-41. doi: 10.1016/j.bmcl.2010.03.017. Epub 2010 Mar 7. Bioorg Med Chem Lett. 2010. PMID: 20359891

5

Pharmacology and in vitro profiling of a novel peroxisome proliferator-activated receptor γ ligand, Cerco-A.

Wakabayashi K, Hayashi S, Matsui Y, Matsumoto T, Furukawa A, Kuroha M, Tanaka N, Inaba T, Kanda S, Tanaka J, Okuyama R, Wakimoto S, Ogata T, Araki K, Ohsumi J. Wakabayashi K, et al. Among authors: tanaka j, tanaka n. Biol Pharm Bull. 2011;34(7):1094-104. doi: 10.1248/bpb.34.1094. Biol Pharm Bull. 2011. PMID: 21720019 Free article.

6

Synthesis and biological evaluation of novel (-)-Cercosporamide derivatives as potent selective PPARγ modulators.

Furukawa A, Arita T, Fukuzaki T, Mori M, Honda T, Satoh S, Matsui Y, Wakabayashi K, Hayashi S, Nakamura K, Araki K, Kuroha M, Tanaka J, Wakimoto S, Suzuki O, Ohsumi J. Furukawa A, et al. Among authors: tanaka j. Eur J Med Chem. 2012 Aug;54:522-33. doi: 10.1016/j.ejmech.2012.05.040. Epub 2012 Jun 7. Eur J Med Chem. 2012. PMID: 22727448

7

Discovery of novel pyridazine derivatives as glucose transporter type 4 (GLUT4) translocation activators.

Tsuji T, Yamaguchi M, Kuroyanagi J, Furuzono S, Konishi M, Terayama K, Tanaka J, Saito M, Kobayashi Y. Tsuji T, et al. Among authors: tanaka j. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1785-1790. doi: 10.1016/j.bmcl.2019.05.013. Epub 2019 May 8. Bioorg Med Chem Lett. 2019. PMID: 31101471

8

Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification.

Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Shimada K, Onishi Y, Matsui Y, Wakimoto S, Kuroha M, Ogata T, Araki K, Ohsumi J, Sawamura R, Watanabe N, Yamamoto H, Fujimoto K, Tani Y, Mori M, Tanaka J. Shinozuka T, et al. Among authors: tanaka j. Bioorg Med Chem. 2018 Oct 1;26(18):5079-5098. doi: 10.1016/j.bmc.2018.09.006. Epub 2018 Sep 8. Bioorg Med Chem. 2018. PMID: 30241907

9

Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition.

Akiu M, Tsuji T, Sogawa Y, Terayama K, Yokoyama M, Tanaka J, Asano D, Sakurai K, Sergienko E, Sessions EH, Gardell SJ, Pinkerton AB, Nakamura T. Akiu M, et al. Among authors: tanaka j. Bioorg Med Chem Lett. 2021 Jul 1;43:128048. doi: 10.1016/j.bmcl.2021.128048. Epub 2021 Apr 19. Bioorg Med Chem Lett. 2021. PMID: 33887438

10

Discovery of DS68702229 as a Potent, Orally Available NAMPT (Nicotinamide Phosphoribosyltransferase) Activator.

Akiu M, Tsuji T, Iida K, Sogawa Y, Terayama K, Yokoyama M, Tanaka J, Asano D, Honda T, Sakurai K, Pinkerton AB, Nakamura T. Akiu M, et al. Among authors: tanaka j. Chem Pharm Bull (Tokyo). 2021;69(11):1110-1122. doi: 10.1248/cpb.c21-00700. Chem Pharm Bull (Tokyo). 2021. PMID: 34719594 Free article.

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