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Page 1
Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities-Report from an ECVAM workshop.
Pfuhler S, Kirkland D, Kasper P, Hayashi M, Vanparys P, Carmichael P, Dertinger S, Eastmond D, Elhajouji A, Krul C, Rothfuss A, Schoening G, Smith A, Speit G, Thomas C, van Benthem J, Corvi R. Pfuhler S, et al. Among authors: van benthem j. Mutat Res. 2009 Nov-Dec;680(1-2):31-42. doi: 10.1016/j.mrgentox.2009.09.002. Epub 2009 Sep 16. Mutat Res. 2009. PMID: 19765670
In vitro genotoxicity test approaches with better predictivity: summary of an IWGT workshop.
Pfuhler S, Fellows M, van Benthem J, Corvi R, Curren R, Dearfield K, Fowler P, Frötschl R, Elhajouji A, Le Hégarat L, Kasamatsu T, Kojima H, Ouédraogo G, Scott A, Speit G. Pfuhler S, et al. Among authors: van benthem j. Mutat Res. 2011 Aug 16;723(2):101-7. doi: 10.1016/j.mrgentox.2011.03.013. Epub 2011 Apr 5. Mutat Res. 2011. PMID: 21473931
Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I. Reports of individual databases presented at an EURL ECVAM Workshop.
Kirkland D, Zeiger E, Madia F, Gooderham N, Kasper P, Lynch A, Morita T, Ouedraogo G, Parra Morte JM, Pfuhler S, Rogiers V, Schulz M, Thybaud V, van Benthem J, Vanparys P, Worth A, Corvi R. Kirkland D, et al. Among authors: van benthem j. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:55-68. doi: 10.1016/j.mrgentox.2014.10.005. Epub 2014 Oct 23. Mutat Res Genet Toxicol Environ Mutagen. 2014. PMID: 25435356 Free article.
Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT).
Pfuhler S, van Benthem J, Curren R, Doak SH, Dusinska M, Hayashi M, Heflich RH, Kidd D, Kirkland D, Luan Y, Ouedraogo G, Reisinger K, Sofuni T, van Acker F, Yang Y, Corvi R. Pfuhler S, et al. Among authors: van benthem j. Mutat Res Genet Toxicol Environ Mutagen. 2020 Feb-Mar;850-851:503135. doi: 10.1016/j.mrgentox.2020.503135. Epub 2020 Jan 15. Mutat Res Genet Toxicol Environ Mutagen. 2020. PMID: 32247552 Free article.
How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.
Kirkland D, Pfuhler S, Tweats D, Aardema M, Corvi R, Darroudi F, Elhajouji A, Glatt H, Hastwell P, Hayashi M, Kasper P, Kirchner S, Lynch A, Marzin D, Maurici D, Meunier JR, Müller L, Nohynek G, Parry J, Parry E, Thybaud V, Tice R, van Benthem J, Vanparys P, White P. Kirkland D, et al. Among authors: van benthem j. Mutat Res. 2007 Mar 30;628(1):31-55. doi: 10.1016/j.mrgentox.2006.11.008. Epub 2007 Jan 13. Mutat Res. 2007. PMID: 17293159
Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests.
Kirkland D, Kasper P, Martus HJ, Müller L, van Benthem J, Madia F, Corvi R. Kirkland D, et al. Among authors: van benthem j. Mutat Res Genet Toxicol Environ Mutagen. 2016 Jan 1;795:7-30. doi: 10.1016/j.mrgentox.2015.10.006. Epub 2015 Nov 4. Mutat Res Genet Toxicol Environ Mutagen. 2016. PMID: 26774663 Free article.
In vivo genotoxicity testing strategies: Report from the 7th International workshop on genotoxicity testing (IWGT).
Kirkland D, Uno Y, Luijten M, Beevers C, van Benthem J, Burlinson B, Dertinger S, Douglas GR, Hamada S, Horibata K, Lovell DP, Manjanatha M, Martus HJ, Mei N, Morita T, Ohyama W, Williams A. Kirkland D, et al. Among authors: van benthem j. Mutat Res Genet Toxicol Environ Mutagen. 2019 Nov;847:403035. doi: 10.1016/j.mrgentox.2019.03.008. Epub 2019 Apr 25. Mutat Res Genet Toxicol Environ Mutagen. 2019. PMID: 31699340
Strategies in case of positive in vivo results in genotoxicity testing.
Thybaud V, Macgregor JT, Müller L, Crebelli R, Dearfield K, Douglas G, Farmer PB, Gocke E, Hayashi M, Lovell DP, Lutz WK, Marzin D, Moore M, Nohmi T, Phillips DH, Van Benthem J. Thybaud V, et al. Among authors: van benthem j. Mutat Res. 2011 Aug 16;723(2):121-8. doi: 10.1016/j.mrgentox.2010.09.002. Epub 2010 Sep 17. Mutat Res. 2011. PMID: 20854927
Application of the adverse outcome pathway framework to genotoxic modes of action.
Sasaki JC, Allemang A, Bryce SM, Custer L, Dearfield KL, Dietz Y, Elhajouji A, Escobar PA, Fornace AJ Jr, Froetschl R, Galloway S, Hemmann U, Hendriks G, Li HH, Luijten M, Ouedraogo G, Peel L, Pfuhler S, Roberts DJ, Thybaud V, van Benthem J, Yauk CL, Schuler M. Sasaki JC, et al. Among authors: van benthem j. Environ Mol Mutagen. 2020 Jan;61(1):114-134. doi: 10.1002/em.22339. Epub 2019 Oct 31. Environ Mol Mutagen. 2020. PMID: 31603995
109 results