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Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists.
Casimiro-Garcia A, Bigge CF, Davis JA, Padalino T, Pulaski J, Ohren JF, McConnell P, Kane CD, Royer LJ, Stevens KA, Auerbach B, Collard W, McGregor C, Song K. Casimiro-Garcia A, et al. Among authors: royer lj. Bioorg Med Chem. 2009 Oct 15;17(20):7113-25. doi: 10.1016/j.bmc.2009.09.001. Epub 2009 Sep 6. Bioorg Med Chem. 2009. PMID: 19783444
Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies.
Casimiro-Garcia A, Bigge CF, Davis JA, Padalino T, Pulaski J, Ohren JF, McConnell P, Kane CD, Royer LJ, Stevens KA, Auerbach BJ, Collard WT, McGregor C, Fakhoury SA, Schaum RP, Zhou H. Casimiro-Garcia A, et al. Among authors: royer lj. Bioorg Med Chem. 2008 May 1;16(9):4883-907. doi: 10.1016/j.bmc.2008.03.043. Epub 2008 Mar 20. Bioorg Med Chem. 2008. PMID: 18394907
Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo.
Kane CD, Stevens KA, Fischer JE, Haghpassand M, Royer LJ, Aldinger C, Landschulz KT, Zagouras P, Bagley SW, Hada W, Dullea R, Hayward CM, Francone OL. Kane CD, et al. Among authors: royer lj. Mol Pharmacol. 2009 Feb;75(2):296-306. doi: 10.1124/mol.108.051656. Epub 2008 Oct 29. Mol Pharmacol. 2009. PMID: 18971326
Pharmacokinetics, disposition and lipid-modulating activity of 5-{2-[4-(3,4-difluorophenoxy)-phenyl]-ethylsulfamoyl}-2-methyl-benzoic acid, a potent and subtype-selective peroxisome proliferator-activated receptor alpha agonist in preclinical species and human.
Frederick KS, Maurer TS, Kalgutkar AS, Royer LJ, Francone OL, Winter SM, Terra SG, Chen D, Gao X. Frederick KS, et al. Among authors: royer lj. Xenobiotica. 2009 Oct;39(10):766-81. doi: 10.1080/00498250903121796. Xenobiotica. 2009. PMID: 19622022
25 results