Koch B - Search Results

1

Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics.

Stephan A, Wermann M, von Bohlen A, Koch B, Cynis H, Demuth HU, Schilling S. Stephan A, et al. Among authors: koch b. FEBS J. 2009 Nov;276(22):6522-36. doi: 10.1111/j.1742-4658.2009.07337.x. Epub 2009 Oct 5. FEBS J. 2009. PMID: 19804409 Free article.

2

Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization.

Schilling S, Lindner C, Koch B, Wermann M, Rahfeld JU, von Bohlen A, Rudolph T, Reuter G, Demuth HU. Schilling S, et al. Among authors: koch b. Biochemistry. 2007 Sep 25;46(38):10921-30. doi: 10.1021/bi701043x. Epub 2007 Aug 28. Biochemistry. 2007. PMID: 17722885

3

Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery.

Cynis H, Rahfeld JU, Stephan A, Kehlen A, Koch B, Wermann M, Demuth HU, Schilling S. Cynis H, et al. Among authors: koch b. J Mol Biol. 2008 Jun 20;379(5):966-80. doi: 10.1016/j.jmb.2008.03.078. Epub 2008 Apr 15. J Mol Biol. 2008. PMID: 18486145

4

Glutaminyl cyclases display significant catalytic proficiency for glutamyl substrates.

Seifert F, Schulz K, Koch B, Manhart S, Demuth HU, Schilling S. Seifert F, et al. Among authors: koch b. Biochemistry. 2009 Dec 22;48(50):11831-3. doi: 10.1021/bi9018835. Biochemistry. 2009. PMID: 19921850

5

Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.

Schilling S, Kohlmann S, Bäuscher C, Sedlmeier R, Koch B, Eichentopf R, Becker A, Cynis H, Hoffmann T, Berg S, Freyse EJ, von Hörsten S, Rossner S, Graubner S, Demuth HU. Schilling S, et al. Among authors: koch b. J Biol Chem. 2011 Apr 22;286(16):14199-208. doi: 10.1074/jbc.M111.229385. Epub 2011 Feb 17. J Biol Chem. 2011. PMID: 21330373 Free PMC article.

6

Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center.

Ruiz-Carrillo D, Koch B, Parthier C, Wermann M, Dambe T, Buchholz M, Ludwig HH, Heiser U, Rahfeld JU, Stubbs MT, Schilling S, Demuth HU. Ruiz-Carrillo D, et al. Among authors: koch b. Biochemistry. 2011 Jul 19;50(28):6280-8. doi: 10.1021/bi200249h. Epub 2011 Jun 27. Biochemistry. 2011. PMID: 21671571

7

Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs.

Koch B, Kolenko P, Buchholz M, Carrillo DR, Parthier C, Wermann M, Rahfeld JU, Reuter G, Schilling S, Stubbs MT, Demuth HU. Koch B, et al. Biochemistry. 2012 Sep 18;51(37):7383-92. doi: 10.1021/bi300687g. Epub 2012 Sep 5. Biochemistry. 2012. PMID: 22897232

8

Probing secondary glutaminyl cyclase (QC) inhibitor interactions applying an in silico-modeling/site-directed mutagenesis approach: implications for drug development.

Koch B, Buchholz M, Wermann M, Heiser U, Schilling S, Demuth HU. Koch B, et al. Chem Biol Drug Des. 2012 Dec;80(6):937-46. doi: 10.1111/cbdd.12046. Epub 2012 Oct 11. Chem Biol Drug Des. 2012. PMID: 22967026

9

Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC.

Höfling C, Indrischek H, Höpcke T, Waniek A, Cynis H, Koch B, Schilling S, Morawski M, Demuth HU, Roßner S, Hartlage-Rübsamen M. Höfling C, et al. Among authors: koch b. Int J Dev Neurosci. 2014 Aug;36:64-73. doi: 10.1016/j.ijdevneu.2014.05.008. Epub 2014 Jun 2. Int J Dev Neurosci. 2014. PMID: 24886834

10

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms.

Hartlage-Rübsamen M, Morawski M, Waniek A, Jäger C, Zeitschel U, Koch B, Cynis H, Schilling S, Schliebs R, Demuth HU, Rossner S. Hartlage-Rübsamen M, et al. Among authors: koch b. Acta Neuropathol. 2011 Jun;121(6):705-19. doi: 10.1007/s00401-011-0806-2. Epub 2011 Feb 8. Acta Neuropathol. 2011. PMID: 21301857 Free PMC article.

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