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Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA.
Vispé S, DeVries L, Créancier L, Besse J, Bréand S, Hobson DJ, Svejstrup JQ, Annereau JP, Cussac D, Dumontet C, Guilbaud N, Barret JM, Bailly C. Vispé S, et al. Among authors: breand s. Mol Cancer Ther. 2009 Oct;8(10):2780-90. doi: 10.1158/1535-7163.MCT-09-0549. Epub 2009 Oct 6. Mol Cancer Ther. 2009. PMID: 19808979
Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2'-deoxycytidine in human leukemic KG1 cells.
Vispé S, Deroide A, Davoine E, Desjobert C, Lestienne F, Fournier L, Novosad N, Bréand S, Besse J, Busato F, Tost J, De Vries L, Cussac D, Riond J, Arimondo PB. Vispé S, et al. Among authors: breand s. Oncotarget. 2015 Jun 20;6(17):15265-82. doi: 10.18632/oncotarget.3317. Oncotarget. 2015. PMID: 25948775 Free PMC article.