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Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA.
Vispé S, DeVries L, Créancier L, Besse J, Bréand S, Hobson DJ, Svejstrup JQ, Annereau JP, Cussac D, Dumontet C, Guilbaud N, Barret JM, Bailly C. Vispé S, et al. Among authors: hobson dj. Mol Cancer Ther. 2009 Oct;8(10):2780-90. doi: 10.1158/1535-7163.MCT-09-0549. Epub 2009 Oct 6. Mol Cancer Ther. 2009. PMID: 19808979
Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration.
Foulds PG, Davidson Y, Mishra M, Hobson DJ, Humphreys KM, Taylor M, Johnson N, Weintraub S, Akiyama H, Arai T, Hasegawa M, Bigio EH, Benson FE, Allsop D, Mann DM. Foulds PG, et al. Among authors: hobson dj. Acta Neuropathol. 2009 Nov;118(5):647-58. doi: 10.1007/s00401-009-0594-0. Epub 2009 Oct 13. Acta Neuropathol. 2009. PMID: 19823856 Free PMC article.