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Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion.
Golding SE, Rosenberg E, Valerie N, Hussaini I, Frigerio M, Cockcroft XF, Chong WY, Hummersone M, Rigoreau L, Menear KA, O'Connor MJ, Povirk LF, van Meter T, Valerie K. Golding SE, et al. Mol Cancer Ther. 2009 Oct;8(10):2894-902. doi: 10.1158/1535-7163.MCT-09-0519. Epub 2009 Oct 6. Mol Cancer Ther. 2009. PMID: 19808981 Free PMC article.
Mutations in the BRCT binding site of BRCA1 result in hyper-recombination.
Dever SM, Golding SE, Rosenberg E, Adams BR, Idowu MO, Quillin JM, Valerie N, Xu B, Povirk LF, Valerie K. Dever SM, et al. Among authors: golding se. Aging (Albany NY). 2011 May;3(5):515-32. doi: 10.18632/aging.100325. Aging (Albany NY). 2011. PMID: 21666281 Free PMC article.
DNA double-strand break - induced pro-survival signaling.
Hawkins AJ, Golding SE, Khalil A, Valerie K. Hawkins AJ, et al. Among authors: golding se. Radiother Oncol. 2011 Oct;101(1):13-7. doi: 10.1016/j.radonc.2011.05.074. Epub 2011 Jul 2. Radiother Oncol. 2011. PMID: 21726915 Free PMC article. Review.
MRE11 and ATM AKTivate pro-survival signaling.
Golding SE, Valerie K. Golding SE, et al. Cell Cycle. 2011 Oct 1;10(19):3227. doi: 10.4161/cc.10.19.17048. Epub 2011 Oct 1. Cell Cycle. 2011. PMID: 21946569 Free PMC article. No abstract available.
36 results