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The role of hypoxia in 2-butoxyethanol-induced hemangiosarcoma.
Laifenfeld D, Gilchrist A, Drubin D, Jorge M, Eddy SF, Frushour BP, Ladd B, Obert LA, Gosink MM, Cook JC, Criswell K, Somps CJ, Koza-Taylor P, Elliston KO, Lawton MP. Laifenfeld D, et al. Among authors: criswell k. Toxicol Sci. 2010 Jan;113(1):254-66. doi: 10.1093/toxsci/kfp213. Epub 2009 Oct 7. Toxicol Sci. 2010. PMID: 19812364 Free PMC article.
Pregabalin induces hepatic hypoxia and increases endothelial cell proliferation in mice, a process inhibited by dietary vitamin E supplementation.
Criswell KA, Cook JC, Morse D, Lawton M, Somps C, Obert L, Roy M, Sokolowski S, Koza-Taylor P, Colangelo J, Navetta K, Brady J, Pegg D, Wojcinski Z, Rahbari R, Duddy S, Anderson T. Criswell KA, et al. Toxicol Sci. 2012 Jul;128(1):42-56. doi: 10.1093/toxsci/kfs148. Epub 2012 Apr 26. Toxicol Sci. 2012. PMID: 22539613
Dysregulated erythropoiesis, macrophage activation, and elevations of tissue growth factors were consistent with the unified mode of action for nongenotoxic hemangiosarcoma recently proposed at an international hemangiosarcoma workshop (Cohen, S. M., Storer, R. D., Criswell …
Dysregulated erythropoiesis, macrophage activation, and elevations of tissue growth factors were consistent with the unified mode of action …
Hemangiosarcoma in rodents: mode-of-action evaluation and human relevance.
Cohen SM, Storer RD, Criswell KA, Doerrer NG, Dellarco VL, Pegg DG, Wojcinski ZW, Malarkey DE, Jacobs AC, Klaunig JE, Swenberg JA, Cook JC. Cohen SM, et al. Toxicol Sci. 2009 Sep;111(1):4-18. doi: 10.1093/toxsci/kfp131. Epub 2009 Jun 12. Toxicol Sci. 2009. PMID: 19525443 Review.
Key components of the mode of action for hemangiosarcoma induction in pregabalin-treated mice: evidence of increased bicarbonate, dysregulated erythropoiesis, macrophage activation, and increased angiogenic growth factors in mice but not in rats.
Criswell KA, Wojcinski Z, Pegg D, Albassam M, Duddy S, Olsen E, Bailie M, Foote S, Anderson T. Criswell KA, et al. Toxicol Sci. 2012 Jul;128(1):22-41. doi: 10.1093/toxsci/kfs147. Epub 2012 Apr 26. Toxicol Sci. 2012. PMID: 22539625
49 results