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Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax.
Zhang Z, Lapolla SM, Annis MG, Truscott M, Roberts GJ, Miao Y, Shao Y, Tan C, Peng J, Johnson AE, Zhang XC, Andrews DW, Lin J. Zhang Z, et al. Among authors: lin j. J Biol Chem. 2004 Oct 15;279(42):43920-8. doi: 10.1074/jbc.M406412200. Epub 2004 Aug 9. J Biol Chem. 2004. PMID: 15302859 Free PMC article.
Bcl-2 changes conformation to inhibit Bax oligomerization.
Dlugosz PJ, Billen LP, Annis MG, Zhu W, Zhang Z, Lin J, Leber B, Andrews DW. Dlugosz PJ, et al. Among authors: lin j. EMBO J. 2006 Jun 7;25(11):2287-96. doi: 10.1038/sj.emboj.7601126. Epub 2006 Apr 27. EMBO J. 2006. PMID: 16642033 Free PMC article.
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