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Page 1
2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors.
Cole AG, Bohnstedt AC, Paradkar V, Kingsbury C, Quintero JG, Park H, Lu Y, You M, Neagu I, Diller DJ, Letourneau JJ, Shao Y, James RA, Riviello CM, Ho KK, Lin TH, Wang B, Appell KC, Sills M, Quadros E, Kimble EF, Ohlmeyer MH, Webb ML. Cole AG, et al. Among authors: kimble ef. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6788-92. doi: 10.1016/j.bmcl.2009.09.080. Epub 2009 Sep 25. Bioorg Med Chem Lett. 2009. PMID: 19836234
Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice.
Lin TH, Hegen M, Quadros E, Nickerson-Nutter CL, Appell KC, Cole AG, Shao Y, Tam S, Ohlmeyer M, Wang B, Goodwin DG, Kimble EF, Quintero J, Gao M, Symanowicz P, Wrocklage C, Lussier J, Schelling SH, Hewet AG, Xuan D, Krykbaev R, Togias J, Xu X, Harrison R, Mansour T, Collins M, Clark JD, Webb ML, Seidl KJ. Lin TH, et al. Among authors: kimble ef. Arthritis Rheum. 2010 Aug;62(8):2283-93. doi: 10.1002/art.27536. Arthritis Rheum. 2010. PMID: 20506481 Free article.
Novel pyrrolidine heterocycles as CCR1 antagonists.
Merritt JR, James R, Paradkar VM, Zhang C, Liu R, Liu J, Jacob B, Chiriac C, Ohlmeyer MJ, Quadros E, Wines P, Postelnek J, Hicks CM, Chen W, Kimble EF, O'Brien L, White N, Desai H, Appell KC, Webb ML. Merritt JR, et al. Among authors: kimble ef. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5477-9. doi: 10.1016/j.bmcl.2010.07.082. Epub 2010 Jul 24. Bioorg Med Chem Lett. 2010. PMID: 20708929
Novel pyrrolidine ureas as C-C chemokine receptor 1 (CCR1) antagonists.
Merritt JR, Liu J, Quadros E, Morris ML, Liu R, Zhang R, Jacob B, Postelnek J, Hicks CM, Chen W, Kimble EF, Rogers WL, O'Brien L, White N, Desai H, Bansal S, King G, Ohlmeyer MJ, Appell KC, Webb ML. Merritt JR, et al. Among authors: kimble ef. J Med Chem. 2009 Mar 12;52(5):1295-301. doi: 10.1021/jm801416q. J Med Chem. 2009. PMID: 19183043
Discovery of 2-aminoimidazopyridine adenosine A(2A) receptor antagonists.
McGuinness BF, Cole AG, Dong G, Brescia MR, Shao Y, Henderson I, Rokosz LL, Stauffer TM, Mannava N, Kimble EF, Hicks C, White N, Wines PG, Quadros E. McGuinness BF, et al. Among authors: kimble ef. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6845-9. doi: 10.1016/j.bmcl.2010.08.064. Epub 2010 Aug 19. Bioorg Med Chem Lett. 2010. PMID: 20869242
Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2.
Esser R, Berry C, Du Z, Dawson J, Fox A, Fujimoto RA, Haston W, Kimble EF, Koehler J, Peppard J, Quadros E, Quintavalla J, Toscano K, Urban L, van Duzer J, Zhang X, Zhou S, Marshall PJ. Esser R, et al. Among authors: kimble ef. Br J Pharmacol. 2005 Feb;144(4):538-50. doi: 10.1038/sj.bjp.0706078. Br J Pharmacol. 2005. PMID: 15655513 Free PMC article.
Novel C5a receptor antagonists regulate neutrophil functions in vitro and in vivo.
Pellas TC, Boyar W, van Oostrum J, Wasvary J, Fryer LR, Pastor G, Sills M, Braunwalder A, Yarwood DR, Kramer R, Kimble E, Hadala J, Haston W, Moreira-Ludewig R, Uziel-Fusi S, Peters P, Bill K, Wennogle LP. Pellas TC, et al. J Immunol. 1998 Jun 1;160(11):5616-21. J Immunol. 1998. PMID: 9605167
27 results