Lin NH - Search Results

1

Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases.

Tao ZF, Hasvold LA, Leverson JD, Han EK, Guan R, Johnson EF, Stoll VS, Stewart KD, Stamper G, Soni N, Bouska JJ, Luo Y, Sowin TJ, Lin NH, Giranda VS, Rosenberg SH, Penning TD. Tao ZF, et al. Among authors: lin nh. J Med Chem. 2009 Nov 12;52(21):6621-36. doi: 10.1021/jm900943h. J Med Chem. 2009. PMID: 19842661

2

Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.

Tong Y, Lin NH, Wang L, Hasvold L, Wang W, Leonard N, Li T, Li Q, Cohen J, Gu WZ, Zhang H, Stoll V, Bauch J, Marsh K, Rosenberg SH, Sham HL. Tong Y, et al. Among authors: lin nh. Bioorg Med Chem Lett. 2003 May 5;13(9):1571-4. doi: 10.1016/s0960-894x(03)00195-1. Bioorg Med Chem Lett. 2003. PMID: 12699757

3

Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.

Hasvold LA, Wang W, Gwaltney SL 2nd, Rockway TW, Nelson LT, Mantei RA, Fakhoury SA, Sullivan GM, Li Q, Lin NH, Wang L, Zhang H, Cohen J, Gu WZ, Marsh K, Bauch J, Rosenberg S, Sham HL. Hasvold LA, et al. Among authors: lin nh. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4001-5. doi: 10.1016/j.bmcl.2003.08.058. Bioorg Med Chem Lett. 2003. PMID: 14592494

4

Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.

Wang L, Wang GT, Wang X, Tong Y, Sullivan G, Park D, Leonard NM, Li Q, Cohen J, Gu WZ, Zhang H, Bauch JL, Jakob CG, Hutchins CW, Stoll VS, Marsh K, Rosenberg SH, Sham HL, Lin NH. Wang L, et al. Among authors: lin nh. J Med Chem. 2004 Jan 29;47(3):612-26. doi: 10.1021/jm030434f. J Med Chem. 2004. PMID: 14736242

5

Synthesis of 1H-pyridin-2-one derivatives as potent and selective farnesyltransferase inhibitors.

Wang L, Lin NH, Li Q, Henry RF, Zhang H, Cohen J, Gu WZ, Marsh KC, Bauch JL, Rosenberg SH, Sham HL. Wang L, et al. Among authors: lin nh. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4603-6. doi: 10.1016/j.bmcl.2004.07.004. Bioorg Med Chem Lett. 2004. PMID: 15324873

6

1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.

Wang GT, Li G, Mantei RA, Chen Z, Kovar P, Gu W, Xiao Z, Zhang H, Sham HL, Sowin T, Rosenberg SH, Lin NH. Wang GT, et al. Among authors: lin nh. J Med Chem. 2005 May 5;48(9):3118-21. doi: 10.1021/jm048989d. J Med Chem. 2005. PMID: 15857116

7

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors.

Li G, Hasvold LA, Tao ZF, Wang GT, Gwaltney SL 2nd, Patel J, Kovar P, Credo RB, Chen Z, Zhang H, Park C, Sham HL, Sowin T, Rosenberg SH, Lin NH. Li G, et al. Among authors: lin nh. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2293-8. doi: 10.1016/j.bmcl.2006.01.028. Epub 2006 Jan 30. Bioorg Med Chem Lett. 2006. PMID: 16446090

8

Chk1 inhibitors for novel cancer treatment.

Tao ZF, Lin NH. Tao ZF, et al. Among authors: lin nh. Anticancer Agents Med Chem. 2006 Jul;6(4):377-88. doi: 10.2174/187152006777698132. Anticancer Agents Med Chem. 2006. PMID: 16842237 Review.

9

Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.

Tong Y, Claiborne A, Stewart KD, Park C, Kovar P, Chen Z, Credo RB, Gu WZ, Gwaltney SL 2nd, Judge RA, Zhang H, Rosenberg SH, Sham HL, Sowin TJ, Lin NH. Tong Y, et al. Among authors: lin nh. Bioorg Med Chem. 2007 Apr 1;15(7):2759-67. doi: 10.1016/j.bmc.2007.01.012. Epub 2007 Jan 17. Bioorg Med Chem. 2007. PMID: 17287122

10

Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors.

Tao ZF, Wang L, Stewart KD, Chen Z, Gu W, Bui MH, Merta P, Zhang H, Kovar P, Johnson E, Park C, Judge R, Rosenberg S, Sowin T, Lin NH. Tao ZF, et al. Among authors: lin nh. J Med Chem. 2007 Apr 5;50(7):1514-27. doi: 10.1021/jm061247v. Epub 2007 Mar 13. J Med Chem. 2007. PMID: 17352464

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