Wan ZL - Search Results

1

Crystal structure of a "nonfoldable" insulin: impaired folding efficiency despite native activity.

Liu M, Wan ZL, Chu YC, Aladdin H, Klaproth B, Choquette M, Hua QX, Mackin RB, Rao JS, De Meyts P, Katsoyannis PG, Arvan P, Weiss MA. Liu M, et al. Among authors: wan zl. J Biol Chem. 2009 Dec 11;284(50):35259-72. doi: 10.1074/jbc.M109.046888. Epub 2009 Oct 22. J Biol Chem. 2009. PMID: 19850922 Free PMC article.

2

Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama.

Wan ZL, Huang K, Xu B, Hu SQ, Wang S, Chu YC, Katsoyannis PG, Weiss MA. Wan ZL, et al. Biochemistry. 2005 Apr 5;44(13):5000-16. doi: 10.1021/bi047585k. Biochemistry. 2005. PMID: 15794638

3

The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition.

Wan ZL, Huang K, Hu SQ, Whittaker J, Weiss MA. Wan ZL, et al. J Biol Chem. 2008 Jul 25;283(30):21198-210. doi: 10.1074/jbc.M800235200. Epub 2008 May 20. J Biol Chem. 2008. PMID: 18492668 Free PMC article.

4

Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.

Zhao M, Wan ZL, Whittaker L, Xu B, Phillips NB, Katsoyannis PG, Ismail-Beigi F, Whittaker J, Weiss MA. Zhao M, et al. Among authors: wan zl. J Biol Chem. 2009 Nov 13;284(46):32178-87. doi: 10.1074/jbc.M109.028399. Epub 2009 Sep 22. J Biol Chem. 2009. PMID: 19773552 Free PMC article.

5

Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.

Phillips NB, Wan ZL, Whittaker L, Hu SQ, Huang K, Hua QX, Whittaker J, Ismail-Beigi F, Weiss MA. Phillips NB, et al. Among authors: wan zl. J Biol Chem. 2010 Apr 16;285(16):11755-9. doi: 10.1074/jbc.C110.105825. Epub 2010 Feb 24. J Biol Chem. 2010. PMID: 20181952 Free PMC article.

6

Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.

Weiss MA, Wan Z, Zhao M, Chu YC, Nakagawa SH, Burke GT, Jia W, Hellmich R, Katsoyannis PG. Weiss MA, et al. J Mol Biol. 2002 Jan 11;315(2):103-11. doi: 10.1006/jmbi.2001.5224. J Mol Biol. 2002. PMID: 11779231

7

Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.

Wan Z, Xu B, Huang K, Chu YC, Li B, Nakagawa SH, Qu Y, Hu SQ, Katsoyannis PG, Weiss MA. Wan Z, et al. Biochemistry. 2004 Dec 28;43(51):16119-33. doi: 10.1021/bi048223f. Biochemistry. 2004. PMID: 15610006

8

Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chain.

Nakagawa SH, Zhao M, Hua QX, Hu SQ, Wan ZL, Jia W, Weiss MA. Nakagawa SH, et al. Among authors: wan zl. Biochemistry. 2005 Apr 5;44(13):4984-99. doi: 10.1021/bi048025o. Biochemistry. 2005. PMID: 15794637 Free PMC article.

9

Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.

Pandyarajan V, Smith BJ, Phillips NB, Whittaker L, Cox GP, Wickramasinghe N, Menting JG, Wan ZL, Whittaker J, Ismail-Beigi F, Lawrence MC, Weiss MA. Pandyarajan V, et al. Among authors: wan zl. J Biol Chem. 2014 Dec 12;289(50):34709-27. doi: 10.1074/jbc.M114.608562. Epub 2014 Oct 10. J Biol Chem. 2014. PMID: 25305014 Free PMC article.

10

Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the mechanism of receptor binding.

Wan ZL, Xu B, Chu YC, Katsoyannis PG, Weiss MA. Wan ZL, et al. Biochemistry. 2003 Nov 11;42(44):12770-83. doi: 10.1021/bi034430o. Biochemistry. 2003. PMID: 14596591

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