Chen W - Search Results

1

Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo.

Morse MA, Wei J, Hartman Z, Xia W, Ren XR, Lei G, Barry WT, Osada T, Hobeika AC, Peplinski S, Jiang H, Devi GR, Chen W, Spector N, Amalfitano A, Lyerly HK, Clay TM. Morse MA, et al. Among authors: chen w. Int J Cancer. 2010 Jun 15;126(12):2893-903. doi: 10.1002/ijc.24995. Int J Cancer. 2010. PMID: 19856307 Free PMC article.

2

Phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibition [corrected].

Hamilton E, Blackwell K, Hobeika AC, Clay TM, Broadwater G, Ren XR, Chen W, Castro H, Lehmann F, Spector N, Wei J, Osada T, Lyerly HK, Morse MA. Hamilton E, et al. Among authors: chen w. J Transl Med. 2012 Feb 10;10:28. doi: 10.1186/1479-5876-10-28. J Transl Med. 2012. PMID: 22325452 Free PMC article. Clinical Trial.

3

Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.

Ren XR, Wei J, Lei G, Wang J, Lu J, Xia W, Spector N, Barak LS, Clay TM, Osada T, Hamilton E, Blackwell K, Hobeika AC, Morse MA, Lyerly HK, Chen W. Ren XR, et al. Among authors: chen w. Breast Cancer Res. 2012 Jun 7;14(3):R89. doi: 10.1186/bcr3204. Breast Cancer Res. 2012. PMID: 22676470 Free PMC article.

4

Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers.

Osada T, Hartman ZC, Wei J, Lei G, Hobeika AC, Gwin WR, Diniz MA, Spector N, Clay TM, Chen W, Morse MA, Lyerly HK. Osada T, et al. Among authors: chen w. Breast Cancer Res. 2018 Aug 9;20(1):90. doi: 10.1186/s13058-018-1023-x. Breast Cancer Res. 2018. PMID: 30092835 Free PMC article.

5

Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.

Osada T, Chen M, Yang XY, Spasojevic I, Vandeusen JB, Hsu D, Clary BM, Clay TM, Chen W, Morse MA, Lyerly HK. Osada T, et al. Among authors: chen m, chen w. Cancer Res. 2011 Jun 15;71(12):4172-82. doi: 10.1158/0008-5472.CAN-10-3978. Epub 2011 Apr 29. Cancer Res. 2011. PMID: 21531761 Free PMC article.

6

Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.

Ren XR, Wang J, Osada T, Mook RA Jr, Morse MA, Barak LS, Lyerly HK, Chen W. Ren XR, et al. Among authors: chen w. Breast Cancer Res. 2015 Feb 15;17(1):20. doi: 10.1186/s13058-015-0528-9. Breast Cancer Res. 2015. PMID: 25849870 Free PMC article.

7

Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.

Mook RA Jr, Wang J, Ren XR, Chen M, Spasojevic I, Barak LS, Lyerly HK, Chen W. Mook RA Jr, et al. Among authors: chen m, chen w. Bioorg Med Chem. 2015 Sep 1;23(17):5829-38. doi: 10.1016/j.bmc.2015.07.001. Epub 2015 Aug 10. Bioorg Med Chem. 2015. PMID: 26272032 Free PMC article.

8

Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy.

Wang J, Ren XR, Piao H, Zhao S, Osada T, Premont RT, Mook RA Jr, Morse MA, Lyerly HK, Chen W. Wang J, et al. Among authors: chen w. Biochem J. 2019 Feb 8;476(3):535-546. doi: 10.1042/BCJ20180385. Biochem J. 2019. PMID: 30635359 Free PMC article.

9

The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

Chen M, Wang J, Lu J, Bond MC, Ren XR, Lyerly HK, Barak LS, Chen W. Chen M, et al. Among authors: chen w. Biochemistry. 2009 Nov 3;48(43):10267-74. doi: 10.1021/bi9009677. Biochemistry. 2009. PMID: 19772353 Free PMC article.

10

Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine.

Wang J, Lu J, Bond MC, Chen M, Ren XR, Lyerly HK, Barak LS, Chen W. Wang J, et al. Among authors: chen m, chen w. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9323-8. doi: 10.1073/pnas.0910712107. Epub 2010 May 3. Proc Natl Acad Sci U S A. 2010. PMID: 20439738 Free PMC article.

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