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Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions.
Cole KP, Groh JM, Johnson MD, Burcham CL, Campbell BM, Diseroad WD, Heller MR, Howell JR, Kallman NJ, Koenig TM, May SA, Miller RD, Mitchell D, Myers DP, Myers SS, Phillips JL, Polster CS, White TD, Cashman J, Hurley D, Moylan R, Sheehan P, Spencer RD, Desmond K, Desmond P, Gowran O. Cole KP, et al. Among authors: diseroad wd. Science. 2017 Jun 16;356(6343):1144-1150. doi: 10.1126/science.aan0745. Science. 2017. PMID: 28619938