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Page 1
Discovery of a novel mechanism of steroid receptor antagonism: WAY-255348 modulates progesterone receptor cellular localization and promoter interactions.
Yudt MR, Russo LA, Berrodin TJ, Jelinsky SA, Ellis D, Cohen JC, Cooch N, Haglund E, Unwalla RJ, Fensome A, Wrobel J, Zhang Z, Nagpal S, Winneker RC. Yudt MR, et al. Among authors: cohen jc. Biochem Pharmacol. 2011 Dec 1;82(11):1709-19. doi: 10.1016/j.bcp.2011.08.006. Epub 2011 Aug 11. Biochem Pharmacol. 2011. PMID: 21854761
Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget.
Zhang Z, Olland AM, Zhu Y, Cohen J, Berrodin T, Chippari S, Appavu C, Li S, Wilhem J, Chopra R, Fensome A, Zhang P, Wrobel J, Unwalla RJ, Lyttle CR, Winneker RC. Zhang Z, et al. Among authors: cohen j. J Biol Chem. 2005 Aug 5;280(31):28468-75. doi: 10.1074/jbc.M504144200. Epub 2005 Jun 3. J Biol Chem. 2005. PMID: 15937332 Free article.
Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal progesterone receptor agonist tanaproget.
Fensome A, Bender R, Chopra R, Cohen J, Collins MA, Hudak V, Malakian K, Lockhead S, Olland A, Svenson K, Terefenko EA, Unwalla RJ, Wilhelm JM, Wolfrom S, Zhu Y, Zhang Z, Zhang P, Winneker RC, Wrobel J. Fensome A, et al. Among authors: cohen j. J Med Chem. 2005 Aug 11;48(16):5092-5. doi: 10.1021/jm050358b. J Med Chem. 2005. PMID: 16078826
Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).
Fensome A, Adams WR, Adams AL, Berrodin TJ, Cohen J, Huselton C, Illenberger A, Kern JC, Hudak VA, Marella MA, Melenski EG, McComas CC, Mugford CA, Slayden OD, Yudt M, Zhang Z, Zhang P, Zhu Y, Winneker RC, Wrobel JE. Fensome A, et al. Among authors: cohen j. J Med Chem. 2008 Mar 27;51(6):1861-73. doi: 10.1021/jm701080t. Epub 2008 Mar 5. J Med Chem. 2008. PMID: 18318463
New progesterone receptor antagonists: 3,3-disubstituted-5-aryloxindoles.
Fensome A, Bender R, Cohen J, Collins MA, Mackner VA, Miller LL, Ullrich JW, Winneker R, Wrobel J, Zhang P, Zhang Z, Zhu Y. Fensome A, et al. Among authors: cohen j. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3487-90. doi: 10.1016/s0960-894x(02)00746-1. Bioorg Med Chem Lett. 2002. PMID: 12419390
Novel pyrrole-containing progesterone receptor modulators.
Collins MA, Hudak V, Bender R, Fensome A, Zhang P, Miller L, Winneker RC, Zhang Z, Zhu Y, Cohen J, Unwalla RJ, Wrobel J. Collins MA, et al. Among authors: cohen j. Bioorg Med Chem Lett. 2004 May 3;14(9):2185-9. doi: 10.1016/j.bmcl.2004.02.054. Bioorg Med Chem Lett. 2004. PMID: 15081005
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