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Page 1
Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents.
Hirai H, Iwasawa Y, Okada M, Arai T, Nishibata T, Kobayashi M, Kimura T, Kaneko N, Ohtani J, Yamanaka K, Itadani H, Takahashi-Suzuki I, Fukasawa K, Oki H, Nambu T, Jiang J, Sakai T, Arakawa H, Sakamoto T, Sagara T, Yoshizumi T, Mizuarai S, Kotani H. Hirai H, et al. Among authors: sakamoto t. Mol Cancer Ther. 2009 Nov;8(11):2992-3000. doi: 10.1158/1535-7163.MCT-09-0463. Epub 2009 Nov 3. Mol Cancer Ther. 2009. PMID: 19887545
Structure-activity relationships of a novel class of endothelin receptor selective antagonists; 6-carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines.
Takahashi H, Ohtake N, Sakamoto T, Iino T, Kawanishi N, Nakamura M, Yoshizumi T, Niiyama K, Ozaki S, Okada H, Kano A, Takahashi H, Ishii Y, Okada M, Saito M, Sawazaki Y, Hayama T, Nishikibe M. Takahashi H, et al. Among authors: sakamoto t. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1503-7. doi: 10.1016/j.bmcl.2004.01.008. Bioorg Med Chem Lett. 2004. PMID: 15006391
Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists.
Suzuki T, Moriya M, Sakamoto T, Suga T, Kishino H, Takahashi H, Ishikawa M, Nagai K, Imai Y, Sekino E, Ito M, Iwaasa H, Ishihara A, Tokita S, Kanatani A, Sato N, Fukami T. Suzuki T, et al. Among authors: sakamoto t. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3072-7. doi: 10.1016/j.bmcl.2009.04.016. Epub 2009 Apr 9. Bioorg Med Chem Lett. 2009. PMID: 19403308
Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.
Sakamoto T, Moriya M, Haga Y, Takahashi T, Shibata T, Okamoto O, Nonoshita K, Kitazawa H, Hidaka M, Gomori A, Iwaasa H, Ishihara A, Kanatani A, Fukami T, Gao YD, Macneil DJ, Yang L. Sakamoto T, et al. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1564-8. doi: 10.1016/j.bmcl.2009.02.035. Epub 2009 Feb 12. Bioorg Med Chem Lett. 2009. PMID: 19243937
Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist.
Haga Y, Sakamoto T, Shibata T, Nonoshita K, Ishikawa M, Suga T, Takahashi H, Takahashi T, Takahashi H, Ando M, Murai T, Gomori A, Oda Z, Kitazawa H, Mitobe Y, Kanesaka M, Ohe T, Iwaasa H, Ishii Y, Ishihara A, Kanatani A, Fukami T. Haga Y, et al. Among authors: sakamoto t. Bioorg Med Chem. 2009 Oct 1;17(19):6971-82. doi: 10.1016/j.bmc.2009.08.019. Epub 2009 Aug 14. Bioorg Med Chem. 2009. PMID: 19720539
Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists.
Kishino H, Moriya M, Sakuraba S, Sakamoto T, Takahashi H, Suzuki T, Moriya R, Ito M, Iwaasa H, Takenaga N, Ishihara A, Kanatani A, Sato N, Fukami T. Kishino H, et al. Among authors: sakamoto t. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4589-93. doi: 10.1016/j.bmcl.2009.06.101. Epub 2009 Jul 4. Bioorg Med Chem Lett. 2009. PMID: 19615899
Novel orally active NPY Y5 receptor antagonists: Synthesis and structure-activity relationship of spiroindoline class compounds.
Sakamoto T, Moriya M, Tsuge H, Takahashi T, Haga Y, Nonoshita K, Okamoto O, Takahashi H, Sakuraba A, Hirohashi T, Shibata T, Kanno T, Ito J, Iwaasa H, Gomori A, Ishihara A, Fukuroda T, Kanatani A, Fukami T. Sakamoto T, et al. Bioorg Med Chem. 2009 Jul 15;17(14):5015-26. doi: 10.1016/j.bmc.2009.05.064. Epub 2009 Jun 2. Bioorg Med Chem. 2009. PMID: 19525116
Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.
Takahashi T, Haga Y, Sakamoto T, Moriya M, Okamoto O, Nonoshita K, Shibata T, Suga T, Takahashi H, Hirohashi T, Sakuraba A, Gomori A, Iwaasa H, Ohe T, Ishihara A, Ishii Y, Kanatani A, Fukami T. Takahashi T, et al. Among authors: sakamoto t. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3511-6. doi: 10.1016/j.bmcl.2009.05.013. Epub 2009 May 9. Bioorg Med Chem Lett. 2009. PMID: 19464889
5,434 results