Sakai Y - Search Results

1

Synthetic prostacycline agonist, ONO-1301, ameliorates left ventricular dysfunction and cardiac fibrosis in cardiomyopathic hamsters.

Hirata Y, Soeki T, Akaike M, Sakai Y, Igarashi T, Sata M. Hirata Y, et al. Among authors: sakai y. Biomed Pharmacother. 2009 Dec;63(10):781-6. doi: 10.1016/j.biopha.2009.09.003. Epub 2009 Oct 13. Biomed Pharmacother. 2009. PMID: 19906506

2

Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice.

Murakami S, Nagaya N, Itoh T, Kataoka M, Iwase T, Horio T, Miyahara Y, Sakai Y, Kangawa K, Kimura H. Murakami S, et al. Among authors: sakai y. Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L59-65. doi: 10.1152/ajplung.00042.2005. Epub 2005 Sep 9. Am J Physiol Lung Cell Mol Physiol. 2006. PMID: 16155090 Free article.

3

A synthetic small molecule, ONO-1301, enhances endogenous growth factor expression and augments angiogenesis in the ischaemic heart.

Nakamura K, Sata M, Iwata H, Sakai Y, Hirata Y, Kugiyama K, Nagai R. Nakamura K, et al. Among authors: sakai y. Clin Sci (Lond). 2007 Jun;112(12):607-16. doi: 10.1042/CS20060301. Clin Sci (Lond). 2007. PMID: 17263691

4

Local delivery of synthetic prostacycline agonist augments collateral growth and improves cardiac function in a swine chronic cardiac ischemia model.

Iwata H, Nakamura K, Sumi M, Ninomiya M, Sakai Y, Hirata Y, Akaike M, Igarashi T, Takamoto S, Nagai R, Sata M. Iwata H, et al. Among authors: sakai y. Life Sci. 2009 Jul 31;85(5-6):255-61. doi: 10.1016/j.lfs.2009.06.002. Epub 2009 Jun 13. Life Sci. 2009. PMID: 19527738

5

A synthetic prostacyclin agonist with thromboxane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/reperfusion injury.

Hirata Y, Shimabukuro M, Uematsu E, Soeki T, Yamada H, Sakai Y, Nakayama M, Matsumoto K, Igarashi T, Sata M. Hirata Y, et al. Among authors: sakai y. Eur J Pharmacol. 2012 Jan 15;674(2-3):352-8. doi: 10.1016/j.ejphar.2011.10.038. Epub 2011 Nov 9. Eur J Pharmacol. 2012. PMID: 22094066

6

Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model.

Hirata Y, Kurobe H, Uematsu E, Yagi S, Soeki T, Yamada H, Fukuda D, Shimabukuro M, Nakayama M, Matsumoto K, Sakai Y, Kitagawa T, Sata M. Hirata Y, et al. Among authors: sakai y. Eur J Pharmacol. 2013 Jan 15;699(1-3):81-7. doi: 10.1016/j.ejphar.2012.11.045. Epub 2012 Dec 5. Eur J Pharmacol. 2013. PMID: 23219794

7

A slow-releasing form of prostacyclin agonist (ONO1301SR) enhances endogenous secretion of multiple cardiotherapeutic cytokines and improves cardiac function in a rapid-pacing-induced model of canine heart failure.

Shirasaka T, Miyagawa S, Fukushima S, Saito A, Shiozaki M, Kawaguchi N, Matsuura N, Nakatani S, Sakai Y, Daimon T, Okita Y, Sawa Y. Shirasaka T, et al. Among authors: sakai y. J Thorac Cardiovasc Surg. 2013 Aug;146(2):413-21. doi: 10.1016/j.jtcvs.2012.10.003. Epub 2013 Mar 28. J Thorac Cardiovasc Surg. 2013. PMID: 23541854 Free article.

8

Impact of cardiac support device combined with slow-release prostacyclin agonist in a canine ischemic cardiomyopathy model.

Kubota Y, Miyagawa S, Fukushima S, Saito A, Watabe H, Daimon T, Sakai Y, Akita T, Sawa Y. Kubota Y, et al. Among authors: sakai y. J Thorac Cardiovasc Surg. 2014 Mar;147(3):1081-7. doi: 10.1016/j.jtcvs.2013.05.035. Epub 2013 Oct 13. J Thorac Cardiovasc Surg. 2014. PMID: 24131787 Free article.

9

Synthetic prostacyclin agonist, ONO1301, enhances endogenous myocardial repair in a hamster model of dilated cardiomyopathy: a promising regenerative therapy for the failing heart.

Ishimaru K, Miyagawa S, Fukushima S, Saito A, Sakai Y, Ueno T, Sawa Y. Ishimaru K, et al. Among authors: sakai y. J Thorac Cardiovasc Surg. 2013 Dec;146(6):1516-25. doi: 10.1016/j.jtcvs.2013.02.045. J Thorac Cardiovasc Surg. 2013. PMID: 24229503 Free article.

10

A sustained-release drug-delivery system of synthetic prostacyclin agonist, ONO-1301SR: a new reagent to enhance cardiac tissue salvage and/or regeneration in the damaged heart.

Fukushima S, Miyagawa S, Sakai Y, Sawa Y. Fukushima S, et al. Among authors: sakai y. Heart Fail Rev. 2015 Jul;20(4):401-13. doi: 10.1007/s10741-015-9477-8. Heart Fail Rev. 2015. PMID: 25708182 Free PMC article. Review.

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