Alexander PA - Search Results

1

A minimal sequence code for switching protein structure and function.

Alexander PA, He Y, Chen Y, Orban J, Bryan PN. Alexander PA, et al. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21149-54. doi: 10.1073/pnas.0906408106. Epub 2009 Nov 18. Proc Natl Acad Sci U S A. 2009. PMID: 19923431 Free PMC article.

2

Directed evolution of highly homologous proteins with different folds by phage display: implications for the protein folding code.

Alexander PA, Rozak DA, Orban J, Bryan PN. Alexander PA, et al. Biochemistry. 2005 Nov 1;44(43):14045-54. doi: 10.1021/bi051231r. Biochemistry. 2005. PMID: 16245920

3

The design and characterization of two proteins with 88% sequence identity but different structure and function.

Alexander PA, He Y, Chen Y, Orban J, Bryan PN. Alexander PA, et al. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11963-8. doi: 10.1073/pnas.0700922104. Epub 2007 Jul 3. Proc Natl Acad Sci U S A. 2007. PMID: 17609385 Free PMC article.

4

Mutational tipping points for switching protein folds and functions.

He Y, Chen Y, Alexander PA, Bryan PN, Orban J. He Y, et al. Among authors: alexander pa. Structure. 2012 Feb 8;20(2):283-91. doi: 10.1016/j.str.2011.11.018. Structure. 2012. PMID: 22325777 Free PMC article.

5

Solution NMR structures of IgG binding domains with artificially evolved high levels of sequence identity but different folds.

He Y, Yeh DC, Alexander P, Bryan PN, Orban J. He Y, et al. Biochemistry. 2005 Nov 1;44(43):14055-61. doi: 10.1021/bi051232j. Biochemistry. 2005. PMID: 16245921

6

NMR structures of two designed proteins with high sequence identity but different fold and function.

He Y, Chen Y, Alexander P, Bryan PN, Orban J. He Y, et al. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14412-7. doi: 10.1073/pnas.0805857105. Epub 2008 Sep 16. Proc Natl Acad Sci U S A. 2008. PMID: 18796611 Free PMC article.

7

Sequence-specific 1H NMR assignments and secondary structure of the streptococcal protein G B2-domain.

Orban J, Alexander P, Bryan P. Orban J, et al. Biochemistry. 1992 Apr 14;31(14):3604-11. doi: 10.1021/bi00129a008. Biochemistry. 1992. PMID: 1314644

8

Structure and dynamics of an acid-denatured protein G mutant.

Sari N, Alexander P, Bryan PN, Orban J. Sari N, et al. Biochemistry. 2000 Feb 8;39(5):965-77. doi: 10.1021/bi9920230. Biochemistry. 2000. PMID: 10653640

9

Engineering subtilisin into a fluoride-triggered processing protease useful for one-step protein purification.

Ruan B, Fisher KE, Alexander PA, Doroshko V, Bryan PN. Ruan B, et al. Among authors: alexander pa. Biochemistry. 2004 Nov 23;43(46):14539-46. doi: 10.1021/bi048177j. Biochemistry. 2004. PMID: 15544324

10

Directed coevolution of stability and catalytic activity in calcium-free subtilisin.

Strausberg SL, Ruan B, Fisher KE, Alexander PA, Bryan PN. Strausberg SL, et al. Among authors: alexander pa. Biochemistry. 2005 Mar 8;44(9):3272-9. doi: 10.1021/bi047806m. Biochemistry. 2005. PMID: 15736937

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