Figuera-Losada M - Search Results

1

Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors.

Kamenecka T, Jiang R, Song X, Duckett D, Chen W, Ling YY, Habel J, Laughlin JD, Chambers J, Figuera-Losada M, Cameron MD, Lin L, Ruiz CH, LoGrasso PV. Kamenecka T, et al. J Med Chem. 2010 Jan 14;53(1):419-31. doi: 10.1021/jm901351f. J Med Chem. 2010. PMID: 19947601 Free PMC article.

2

Selective inhibition of mitochondrial JNK signaling achieved using peptide mimicry of the Sab kinase interacting motif-1 (KIM1).

Chambers JW, Cherry L, Laughlin JD, Figuera-Losada M, Lograsso PV. Chambers JW, et al. Among authors: figuera losada m. ACS Chem Biol. 2011 Aug 19;6(8):808-18. doi: 10.1021/cb200062a. Epub 2011 May 24. ACS Chem Biol. 2011. PMID: 21563797 Free PMC article.

3

Enzyme kinetics and interaction studies for human JNK1β1 and substrates activating transcription factor 2 (ATF2) and c-Jun N-terminal kinase (c-Jun).

Figuera-Losada M, LoGrasso PV. Figuera-Losada M, et al. J Biol Chem. 2012 Apr 13;287(16):13291-302. doi: 10.1074/jbc.M111.323766. Epub 2012 Feb 17. J Biol Chem. 2012. PMID: 22351776 Free PMC article.

4

Structural mechanisms of allostery and autoinhibition in JNK family kinases.

Laughlin JD, Nwachukwu JC, Figuera-Losada M, Cherry L, Nettles KW, LoGrasso PV. Laughlin JD, et al. Among authors: figuera losada m. Structure. 2012 Dec 5;20(12):2174-84. doi: 10.1016/j.str.2012.09.021. Epub 2012 Nov 8. Structure. 2012. PMID: 23142346 Free PMC article.

5

A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases.

Feng Y, Chambers JW, Iqbal S, Koenig M, Park H, Cherry L, Hernandez P, Figuera-Losada M, LoGrasso PV. Feng Y, et al. Among authors: figuera losada m. ACS Chem Biol. 2013 Aug 16;8(8):1747-54. doi: 10.1021/cb3006165. Epub 2013 Jun 10. ACS Chem Biol. 2013. PMID: 23751758 Free PMC article.

6

The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain.

Fu Q, Figuera-Losada M, Ploplis VA, Cnudde S, Geiger JH, Prorok M, Castellino FJ. Fu Q, et al. J Biol Chem. 2008 Jan 18;283(3):1580-1587. doi: 10.1074/jbc.M705063200. Epub 2007 Nov 26. J Biol Chem. 2008. PMID: 18039665 Free article.

7

Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM).

Figuera-Losada M, Ranson M, Sanderson-Smith ML, Walker MJ, Castellino FJ, Prorok M. Figuera-Losada M, et al. Biochim Biophys Acta. 2010 Jun;1804(6):1342-9. doi: 10.1016/j.bbapap.2010.01.019. Epub 2010 Feb 10. Biochim Biophys Acta. 2010. PMID: 20152941 Free PMC article.

8

Reasons for ineligibility for clinical trials of patients with medication-resistant epilepsy.

Kerr WT, Chen H, Figuera Losada M, Cheng C, Liu T, French J. Kerr WT, et al. Among authors: figuera losada m. Epilepsia. 2023 May;64(5):e56-e60. doi: 10.1111/epi.17568. Epub 2023 Mar 17. Epilepsia. 2023. PMID: 36869635

9

Management of sleep apnea in New York City during the COVID-19 pandemic.

Thorpy M, Figuera-Losada M, Ahmed I, Monderer R, Petrisko M, Martin C, Akhtar J, Thorpy J, Haines C. Thorpy M, et al. Among authors: figuera losada m. Sleep Med. 2020 Oct;74:86-90. doi: 10.1016/j.sleep.2020.07.013. Epub 2020 Jul 18. Sleep Med. 2020. PMID: 32841850 Free PMC article.

10

Development of a primary microglia screening assay and its use to characterize inhibition of system x_c^- by erastin and its analogs.

Figuera-Losada M, Thomas AG, Stathis M, Stockwell BR, Rojas C, Slusher BS. Figuera-Losada M, et al. Biochem Biophys Rep. 2017 Jan 17;9:266-272. doi: 10.1016/j.bbrep.2016.12.009. eCollection 2017 Mar. Biochem Biophys Rep. 2017. PMID: 28956014 Free PMC article.

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