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Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis.
Lippens S, Lefebvre S, Gilbert B, Sze M, Devos M, Verhelst K, Vereecke L, Mc Guire C, Guérin C, Vandenabeele P, Pasparakis M, Mikkola ML, Beyaert R, Declercq W, van Loo G. Lippens S, et al. Among authors: sze m. Cell Death Differ. 2011 Dec;18(12):1845-53. doi: 10.1038/cdd.2011.55. Epub 2011 May 13. Cell Death Differ. 2011. PMID: 21566665 Free PMC article.
The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity.
Kool M, van Loo G, Waelput W, De Prijck S, Muskens F, Sze M, van Praet J, Branco-Madeira F, Janssens S, Reizis B, Elewaut D, Beyaert R, Hammad H, Lambrecht BN. Kool M, et al. Among authors: sze m. Immunity. 2011 Jul 22;35(1):82-96. doi: 10.1016/j.immuni.2011.05.013. Epub 2011 Jun 30. Immunity. 2011. PMID: 21723156 Free article.
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis.
Matmati M, Jacques P, Maelfait J, Verheugen E, Kool M, Sze M, Geboes L, Louagie E, Mc Guire C, Vereecke L, Chu Y, Boon L, Staelens S, Matthys P, Lambrecht BN, Schmidt-Supprian M, Pasparakis M, Elewaut D, Beyaert R, van Loo G. Matmati M, et al. Among authors: sze m. Nat Genet. 2011 Aug 14;43(9):908-12. doi: 10.1038/ng.874. Nat Genet. 2011. PMID: 21841782
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.
Takahashi N, Vereecke L, Bertrand MJ, Duprez L, Berger SB, Divert T, Gonçalves A, Sze M, Gilbert B, Kourula S, Goossens V, Lefebvre S, Günther C, Becker C, Bertin J, Gough PJ, Declercq W, van Loo G, Vandenabeele P. Takahashi N, et al. Among authors: sze m. Nature. 2014 Sep 4;513(7516):95-9. doi: 10.1038/nature13706. Nature. 2014. PMID: 25186904
A20 controls intestinal homeostasis through cell-specific activities.
Vereecke L, Vieira-Silva S, Billiet T, van Es JH, Mc Guire C, Slowicka K, Sze M, van den Born M, De Hertogh G, Clevers H, Raes J, Rutgeerts P, Vermeire S, Beyaert R, van Loo G. Vereecke L, et al. Among authors: sze m. Nat Commun. 2014 Sep 30;5:5103. doi: 10.1038/ncomms6103. Nat Commun. 2014. PMID: 25267258 Free article.
96 results