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448 results

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Page 1
The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2.
D'Alessandro PL, Corti C, Roth A, Ugolini A, Sava A, Montanari D, Bianchi F, Garland SL, Powney B, Koppe EL, Rocheville M, Osborne G, Perez P, de la Fuente J, De Los Frailes M, Smith PW, Branch C, Nash D, Watson SP. D'Alessandro PL, et al. Among authors: smith pw. Bioorg Med Chem Lett. 2010 Jan 15;20(2):759-62. doi: 10.1016/j.bmcl.2009.11.032. Epub 2009 Nov 26. Bioorg Med Chem Lett. 2010. PMID: 20005096
The identification of novel orally active mGluR5 antagonist GSK2210875.
Pilla M, Andreoli M, Tessari M, Delle-Fratte S, Roth A, Butler S, Brown F, Shah P, Bettini E, Cavallini P, Benedetti R, Minick D, Smith P, Tehan B, D'Alessandro P, Lorthioir O, Ball C, Garzya V, Goodacre C, Watson S. Pilla M, et al. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7521-4. doi: 10.1016/j.bmcl.2010.09.120. Epub 2010 Nov 2. Bioorg Med Chem Lett. 2010. PMID: 21051228
The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist.
Rimland J, Dunne A, Hunjan SS, Sasse R, Uings I, Montanari D, Caivano M, Shah P, Standing D, Gray D, Brown D, Cairns W, Trump R, Smith PW, Bertheleme N, D'Alessandro P, Gul S, Vimal M, Smith DN, Watson SP. Rimland J, et al. Among authors: smith pw, smith dn. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2340-3. doi: 10.1016/j.bmcl.2010.01.133. Epub 2010 Feb 4. Bioorg Med Chem Lett. 2010. PMID: 20202837
Identification of a potent and selective 5-HT1B receptor antagonist.
Wyman PA, Marshall HR, Flynn ST, King RJ, Thompson M, Smith PW, Hadley MS, Price GW, Scott CM, Dawson LA. Wyman PA, et al. Among authors: smith pw. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4708-12. doi: 10.1016/j.bmcl.2005.07.085. Bioorg Med Chem Lett. 2005. PMID: 16153839
Studies on a series of potent, orally bioavailable, 5-HT(1) receptor ligands.
Ward SE, Johnson CN, Lovell PJ, Scott CM, Smith PW, Stemp G, Thewlis KM, Vong AK, Watson JM. Ward SE, et al. Among authors: smith pw. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5214-7. doi: 10.1016/j.bmcl.2007.06.078. Epub 2007 Jun 30. Bioorg Med Chem Lett. 2007. PMID: 17629698
Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator.
Ward SE, Harries M, Aldegheri L, Andreotti D, Ballantine S, Bax BD, Harris AJ, Harker AJ, Lund J, Melarange R, Mingardi A, Mookherjee C, Mosley J, Neve M, Oliosi B, Profeta R, Smith KJ, Smith PW, Spada S, Thewlis KM, Yusaf SP. Ward SE, et al. Among authors: smith kj, smith pw. J Med Chem. 2010 Aug 12;53(15):5801-12. doi: 10.1021/jm1005429. J Med Chem. 2010. PMID: 20614889 Clinical Trial.
New quinoline NK3 receptor antagonists with CNS activity.
Smith PW, Wyman PA, Lovell P, Goodacre C, Serafinowska HT, Vong A, Harrington F, Flynn S, Bradley DM, Porter R, Coggon S, Murkitt G, Searle K, Thomas DR, Watson JM, Martin W, Wu Z, Dawson LA. Smith PW, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):837-40. doi: 10.1016/j.bmcl.2008.12.005. Epub 2008 Dec 7. Bioorg Med Chem Lett. 2009. PMID: 19117759
448 results