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493 results

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Page 1
The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2.
D'Alessandro PL, Corti C, Roth A, Ugolini A, Sava A, Montanari D, Bianchi F, Garland SL, Powney B, Koppe EL, Rocheville M, Osborne G, Perez P, de la Fuente J, De Los Frailes M, Smith PW, Branch C, Nash D, Watson SP. D'Alessandro PL, et al. Among authors: watson sp. Bioorg Med Chem Lett. 2010 Jan 15;20(2):759-62. doi: 10.1016/j.bmcl.2009.11.032. Epub 2009 Nov 26. Bioorg Med Chem Lett. 2010. PMID: 20005096
The identification of novel orally active mGluR5 antagonist GSK2210875.
Pilla M, Andreoli M, Tessari M, Delle-Fratte S, Roth A, Butler S, Brown F, Shah P, Bettini E, Cavallini P, Benedetti R, Minick D, Smith P, Tehan B, D'Alessandro P, Lorthioir O, Ball C, Garzya V, Goodacre C, Watson S. Pilla M, et al. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7521-4. doi: 10.1016/j.bmcl.2010.09.120. Epub 2010 Nov 2. Bioorg Med Chem Lett. 2010. PMID: 21051228
The identification of a series of novel, soluble non-peptidic neuropeptide Y Y2 receptor antagonists.
Lunniss GE, Barnes AA, Barton N, Biagetti M, Bianchi F, Blowers SM, Caberlotto LL, Emmons A, Holmes IP, Montanari D, Norris R, Puckey GV, Walters DJ, Watson SP, Willis J. Lunniss GE, et al. Among authors: watson sp. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7341-4. doi: 10.1016/j.bmcl.2010.10.065. Epub 2010 Nov 10. Bioorg Med Chem Lett. 2010. PMID: 21074426
The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist.
Rimland J, Dunne A, Hunjan SS, Sasse R, Uings I, Montanari D, Caivano M, Shah P, Standing D, Gray D, Brown D, Cairns W, Trump R, Smith PW, Bertheleme N, D'Alessandro P, Gul S, Vimal M, Smith DN, Watson SP. Rimland J, et al. Among authors: watson sp. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2340-3. doi: 10.1016/j.bmcl.2010.01.133. Epub 2010 Feb 4. Bioorg Med Chem Lett. 2010. PMID: 20202837
The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists.
Johnson DJ, Forbes IT, Watson SP, Garzya V, Stevenson GI, Walker GR, Mudhar HS, Flynn ST, Wyman PA, Smith PW, Murkitt GS, Lucas AJ, Mookherjee CR, Watson JM, Gartlon JE, Bradford AM, Brown F. Johnson DJ, et al. Among authors: watson sp, watson jm. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5434-8. doi: 10.1016/j.bmcl.2010.07.097. Epub 2010 Jul 30. Bioorg Med Chem Lett. 2010. PMID: 20709550
The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin.
Schrøder TJ, Christensen S, Lindberg S, Langgård M, David L, Maltas PJ, Eskildsen J, Jacobsen J, Tagmose L, Simonsen KB, Biilmann Rønn LC, de Jong IE, Malik IJ, Karlsson JJ, Bundgaard C, Egebjerg J, Stavenhagen JB, Strandbygård D, Thirup S, Andersen JL, Uppalanchi S, Pervaram S, Kasturi SP, Eradi P, Sakumudi DR, Watson SP. Schrøder TJ, et al. Among authors: watson sp. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80. doi: 10.1016/j.bmcl.2013.11.046. Epub 2013 Nov 27. Bioorg Med Chem Lett. 2014. PMID: 24355129
The characterization of a novel V1b antagonist lead series.
Smethurst CA, Borthwick JA, Gaines S, Watson S, Green A, Schulz MJ, Burton G, Buson AA, Arban R. Smethurst CA, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):92-6. doi: 10.1016/j.bmcl.2010.11.061. Epub 2010 Nov 19. Bioorg Med Chem Lett. 2011. PMID: 21146408
The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure.
Holmes IP, Blunt RJ, Lorthioir OE, Blowers SM, Gribble A, Payne AH, Stansfield IG, Wood M, Woollard PM, Reavill C, Howes CM, Micheli F, Di Fabio R, Donati D, Terreni S, Hamprecht D, Arista L, Worby A, Watson SP. Holmes IP, et al. Among authors: watson sp. Bioorg Med Chem Lett. 2010 Mar 15;20(6):2013-6. doi: 10.1016/j.bmcl.2010.01.090. Epub 2010 Jan 25. Bioorg Med Chem Lett. 2010. PMID: 20153647
Identification of novel pyrazole acid antagonists for the EP1 receptor.
McKeown SC, Hall A, Giblin GM, Lorthioir O, Blunt R, Lewell XQ, Wilson RJ, Brown SH, Chowdhury A, Coleman T, Watson SP, Chessell IP, Pipe A, Clayton N, Goldsmith P. McKeown SC, et al. Among authors: watson sp. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4767-71. doi: 10.1016/j.bmcl.2006.06.086. Epub 2006 Jul 14. Bioorg Med Chem Lett. 2006. PMID: 16843659
493 results