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Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Schnute ME, O'Brien PM, Nahra J, Morris M, Howard Roark W, Hanau CE, Ruminski PG, Scholten JA, Fletcher TR, Hamper BC, Carroll JN, Patt WC, Shieh HS, Collins B, Pavlovsky AG, Palmquist KE, Aston KW, Hitchcock J, Rogers MD, McDonald J, Johnson AR, Munie GE, Wittwer AJ, Man CF, Settle SL, Nemirovskiy O, Vickery LE, Agawal A, Dyer RD, Sunyer T. Schnute ME, et al. Among authors: aston kw. Bioorg Med Chem Lett. 2010 Jan 15;20(2):576-80. doi: 10.1016/j.bmcl.2009.11.081. Epub 2009 Nov 22. Bioorg Med Chem Lett. 2010. PMID: 20005097
Fluorescence assay of polyamide-DNA interactions.
Dupureur CM, Bashkin JK, Aston K, Koeller KJ, Gaston KR, He G. Dupureur CM, et al. Anal Biochem. 2012 Apr 1;423(1):178-83. doi: 10.1016/j.ab.2012.01.017. Epub 2012 Jan 28. Anal Biochem. 2012. PMID: 22342620 Free PMC article.
14 results