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Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models.
Kataura T, Sedlackova L, Sun C, Kocak G, Wilson N, Banks P, Hayat F, Trushin S, Trushina E, Maddocks ODK, Oblong JE, Miwa S, Imoto M, Saiki S, Erskine D, Migaud ME, Sarkar S, Korolchuk VI. Kataura T, et al. Among authors: korolchuk vi. Cell Death Dis. 2024 May 31;15(5):382. doi: 10.1038/s41419-024-06770-y. Cell Death Dis. 2024. PMID: 38821960 Free PMC article.
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency.
Sun C, Seranova E, Cohen MA, Chipara M, Roberts J, Astuti D, Palhegyi AM, Acharjee A, Sedlackova L, Kataura T, Otten EG, Panda PK, Lara-Reyna S, Korsgen ME, Kauffman KJ, Huerta-Uribe A, Zatyka M, Silva LFSE, Torresi J, Zhang S, Hughes GW, Ward C, Kuechler ER, Cartwright D, Trushin S, Trushina E, Sahay G, Buganim Y, Lavery GG, Gsponer J, Anderson DG, Frickel EM, Rosenstock TR, Barrett T, Maddocks ODK, Tennant DA, Wang H, Jaenisch R, Korolchuk VI, Sarkar S. Sun C, et al. Among authors: korolchuk vi. Cell Rep. 2023 May 30;42(5):112372. doi: 10.1016/j.celrep.2023.112372. Epub 2023 Apr 21. Cell Rep. 2023. PMID: 37086404 Free PMC article.
NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy.
Kataura T, Otten EG, Rabanal-Ruiz Y, Adriaenssens E, Urselli F, Scialo F, Fan L, Smith GR, Dawson WM, Chen X, Yue WW, Bronowska AK, Carroll B, Martens S, Lazarou M, Korolchuk VI. Kataura T, et al. Among authors: korolchuk vi. EMBO J. 2023 Mar 1;42(5):e111372. doi: 10.15252/embj.2022111372. Epub 2022 Dec 14. EMBO J. 2023. PMID: 36514953 Free PMC article.
In search of an "autophagomometer".
Rubinsztein DC, Cuervo AM, Ravikumar B, Sarkar S, Korolchuk V, Kaushik S, Klionsky DJ. Rubinsztein DC, et al. Autophagy. 2009 Jul;5(5):585-9. doi: 10.4161/auto.5.5.8823. Epub 2009 Jul 23. Autophagy. 2009. PMID: 19411822 Free article.
101 results