Greenlee W - Search Results

1

Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation.

Zhu Z, Sun ZY, Ye Y, Voigt J, Strickland C, Smith EM, Cumming J, Wang L, Wong J, Wang YS, Wyss DF, Chen X, Kuvelkar R, Kennedy ME, Favreau L, Parker E, McKittrick BA, Stamford A, Czarniecki M, Greenlee W, Hunter JC. Zhu Z, et al. Among authors: greenlee w. J Med Chem. 2010 Feb 11;53(3):951-65. doi: 10.1021/jm901408p. J Med Chem. 2010. PMID: 20043696

2

Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors.

Weber AE, Halgren TA, Doyle JJ, Lynch RJ, Siegl PK, Parsons WH, Greenlee WJ, Patchett AA. Weber AE, et al. Among authors: greenlee wj. J Med Chem. 1991 Sep;34(9):2692-701. doi: 10.1021/jm00113a005. J Med Chem. 1991. PMID: 1895289

3

Triazolinone biphenylsulfonamide derivatives as orally active angiotensin II antagonists with potent AT1 receptor affinity and enhanced AT2 affinity.

Ashton WT, Chang LL, Flanagan KL, Hutchins SM, Naylor EM, Chakravarty PK, Patchett AA, Greenlee WJ, Chen TB, Faust KA, et al. Ashton WT, et al. Among authors: greenlee wj. J Med Chem. 1994 Aug 19;37(17):2808-24. doi: 10.1021/jm00043a020. J Med Chem. 1994. PMID: 8064808

4

Triazolinones as nonpeptide angiotensin II antagonists. 1. Synthesis and evaluation of potent 2,4,5-trisubstituted triazolinones.

Chang LL, Ashton WT, Flanagan KL, Strelitz RA, MacCoss M, Greenlee WJ, Chang RS, Lotti VJ, Faust KA, Chen TB, et al. Chang LL, et al. Among authors: greenlee wj. J Med Chem. 1993 Aug 20;36(17):2558-68. doi: 10.1021/jm00069a015. J Med Chem. 1993. PMID: 8355255

5

Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists.

Wang Y, Chackalamannil S, Hu Z, Clader JW, Greenlee W, Billard W, Binch H, Crosby G, Ruperto V, Duffy RA, McQuade R, Lachowicz JE. Wang Y, et al. Among authors: greenlee w. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2247-50. doi: 10.1016/s0960-894x(00)00457-1. Bioorg Med Chem Lett. 2000. PMID: 11055330

6

Design and synthesis of ether analogues as potent and selective M2 muscarinic receptor antagonists.

Wang Y, Chackalamannil S, Chang W, Greenlee W, Ruperto V, Duffy RA, McQuade R, Lachowicz JE. Wang Y, et al. Among authors: greenlee w. Bioorg Med Chem Lett. 2001 Apr 9;11(7):891-4. doi: 10.1016/s0960-894x(01)00100-7. Bioorg Med Chem Lett. 2001. PMID: 11294385

7

Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution.

Boyle CD, Chackalamannil S, Clader JW, Greenlee WJ, Josien HB, Kaminski JJ, Kozlowski JA, McCombie SW, Nazareno DV, Tagat JR, Wang Y, Zhou G, Billard W, Binch H, Crosby G, Cohen-Williams M, Coffin VL, Cox KA, Grotz DE, Duffy RA, Ruperto V, Lachowicz JE. Boyle CD, et al. Among authors: greenlee wj. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2311-4. doi: 10.1016/s0960-894x(01)00435-8. Bioorg Med Chem Lett. 2001. PMID: 11527721

8

Discovery of 4-[(Z)-(4-bromophenyl)- (ethoxyimino)methyl]-1'-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4'-methyl-1,4'- bipiperidine N-oxide (SCH 351125): an orally bioavailable human CCR5 antagonist for the treatment of HIV infection.

Palani A, Shapiro S, Clader JW, Greenlee WJ, Cox K, Strizki J, Endres M, Baroudy BM. Palani A, et al. Among authors: greenlee wj. J Med Chem. 2001 Oct 11;44(21):3339-42. doi: 10.1021/jm015526o. J Med Chem. 2001. PMID: 11585437

9

Sulfide analogues as potent and selective M(2) muscarinic receptor antagonists.

Wang Y, Chackalamannil S, Hu Z, McKittrick BA, Greenlee W, Ruperto V, Duffy RA, Lachowicz JE. Wang Y, et al. Among authors: greenlee w. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1087-91. doi: 10.1016/s0960-894x(02)00096-3. Bioorg Med Chem Lett. 2002. PMID: 11909724

10

Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity.

Palani A, Shapiro S, Josien H, Bara T, Clader JW, Greenlee WJ, Cox K, Strizki JM, Baroudy BM. Palani A, et al. Among authors: greenlee wj. J Med Chem. 2002 Jul 4;45(14):3143-60. doi: 10.1021/jm0200815. J Med Chem. 2002. PMID: 12086500

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