Howlett AR - Search Results

1

Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo.

Scatena CD, Kumer JL, Arbitrario JP, Howlett AR, Hawtin RE, Fox JA, Silverman JA. Scatena CD, et al. Among authors: howlett ar. Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8. doi: 10.1007/s00280-009-1234-z. Epub 2010 Jan 8. Cancer Chemother Pharmacol. 2010. PMID: 20058009 Free PMC article.

2

SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo.

Arbitrario JP, Belmont BJ, Evanchik MJ, Flanagan WM, Fucini RV, Hansen SK, Harris SO, Hashash A, Hoch U, Hogan JN, Howlett AR, Jacobs JW, Lam JW, Ritchie SC, Romanowski MJ, Silverman JA, Stockett DE, Teague JN, Zimmerman KM, Taverna P. Arbitrario JP, et al. Among authors: howlett ar. Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17. doi: 10.1007/s00280-009-1076-8. Epub 2009 Aug 1. Cancer Chemother Pharmacol. 2010. PMID: 19649632

3

A selective and oral small molecule inhibitor of vascular epithelial growth factor receptor (VEGFR)-2 and VEGFR-1 inhibits neovascularization and vascular permeability.

Patel N, Sun L, Moshinsky D, Chen H, Leahy KM, Le P, Moss KG, Wang X, Rice A, Tam D, Laird AD, Yu X, Zhang Q, Tang C, McMahon G, Howlett A. Patel N, et al. J Pharmacol Exp Ther. 2003 Sep;306(3):838-45. doi: 10.1124/jpet.103.052167. Epub 2003 May 23. J Pharmacol Exp Ther. 2003. PMID: 12766257

4

Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion.

Wang X, Le P, Liang C, Chan J, Kiewlich D, Miller T, Harris D, Sun L, Rice A, Vasile S, Blake RA, Howlett AR, Patel N, McMahon G, Lipson KE. Wang X, et al. Among authors: howlett ar. Mol Cancer Ther. 2003 Nov;2(11):1085-92. Mol Cancer Ther. 2003. PMID: 14617781

5

SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro.

Abdollahi A, Lipson KE, Han X, Krempien R, Trinh T, Weber KJ, Hahnfeldt P, Hlatky L, Debus J, Howlett AR, Huber PE. Abdollahi A, et al. Among authors: howlett ar. Cancer Res. 2003 Jul 1;63(13):3755-63. Cancer Res. 2003. PMID: 12839971

6

The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants.

Berthou S, Aebersold DM, Schmidt LS, Stroka D, Heigl C, Streit B, Stalder D, Gruber G, Liang C, Howlett AR, Candinas D, Greiner RH, Lipson KE, Zimmer Y. Berthou S, et al. Among authors: howlett ar. Oncogene. 2004 Jul 8;23(31):5387-93. doi: 10.1038/sj.onc.1207691. Oncogene. 2004. PMID: 15064724

7

SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization.

Ismail IH, Mårtensson S, Moshinsky D, Rice A, Tang C, Howlett A, McMahon G, Hammarsten O. Ismail IH, et al. Oncogene. 2004 Jan 29;23(4):873-82. doi: 10.1038/sj.onc.1207303. Oncogene. 2004. PMID: 14661061

8

The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion.

Wright JH, Wang X, Manning G, LaMere BJ, Le P, Zhu S, Khatry D, Flanagan PM, Buckley SD, Whyte DB, Howlett AR, Bischoff JR, Lipson KE, Jallal B. Wright JH, et al. Among authors: howlett ar. Mol Cell Biol. 2003 Mar;23(6):2068-82. doi: 10.1128/MCB.23.6.2068-2082.2003. Mol Cell Biol. 2003. PMID: 12612079 Free PMC article.

9

Improved effect of an antiangiogenic tyrosine kinase inhibitor (SU5416) by combinations with fractionated radiotherapy or low molecular weight heparin.

Lund EL, Olsen MW, Lipson KE, McMahon G, Howlett AR, Kristjansen PE. Lund EL, et al. Among authors: howlett ar. Neoplasia. 2003 Mar-Apr;5(2):155-60. doi: 10.1016/s1476-5586(03)80007-6. Neoplasia. 2003. PMID: 12659688 Free PMC article.

10

Adventitial microvessel formation after coronary stenting and the effects of SU11218, a tyrosine kinase inhibitor.

Cheema AN, Hong T, Nili N, Segev A, Moffat JG, Lipson KE, Howlett AR, Holdsworth DW, Cole MJ, Qiang B, Kolodgie F, Virmani R, Stewart DJ, Strauss BH. Cheema AN, et al. Among authors: howlett ar. J Am Coll Cardiol. 2006 Mar 7;47(5):1067-75. doi: 10.1016/j.jacc.2005.08.076. Epub 2006 Feb 9. J Am Coll Cardiol. 2006. PMID: 16516095 Free article.

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