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Synthesis and optimization of hyaluronic acid-methotrexate conjugates to maximize benefit in the treatment of osteoarthritis.
Homma A, Sato H, Tamura T, Okamachi A, Emura T, Ishizawa T, Kato T, Matsuura T, Sato S, Higuchi Y, Watanabe T, Kitamura H, Asanuma K, Yamazaki T, Ikemi M, Kitagawa H, Morikawa T, Ikeya H, Maeda K, Takahashi K, Nohmi K, Izutani N, Kanda M, Suzuki R. Homma A, et al. Among authors: izutani n. Bioorg Med Chem. 2010 Feb;18(3):1062-75. doi: 10.1016/j.bmc.2009.12.053. Epub 2009 Dec 28. Bioorg Med Chem. 2010. PMID: 20060728
Novel hyaluronic acid-methotrexate conjugates for osteoarthritis treatment.
Homma A, Sato H, Okamachi A, Emura T, Ishizawa T, Kato T, Matsuura T, Sato S, Tamura T, Higuchi Y, Watanabe T, Kitamura H, Asanuma K, Yamazaki T, Ikemi M, Kitagawa H, Morikawa T, Ikeya H, Maeda K, Takahashi K, Nohmi K, Izutani N, Kanda M, Suzuki R. Homma A, et al. Among authors: izutani n. Bioorg Med Chem. 2009 Jul 1;17(13):4647-56. doi: 10.1016/j.bmc.2009.04.063. Epub 2009 May 3. Bioorg Med Chem. 2009. PMID: 19457673
18 results