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346 results

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Page 1
The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.
Larson ET, Mudeppa DG, Gillespie JR, Mueller N, Napuli AJ, Arif JA, Ross J, Arakaki TL, Lauricella A, Detitta G, Luft J, Zucker F, Verlinde CL, Fan E, Van Voorhis WC, Buckner FS, Rathod PK, Hol WG, Merritt EA. Larson ET, et al. Among authors: hol wg. J Mol Biol. 2010 Mar 12;396(5):1244-59. doi: 10.1016/j.jmb.2010.01.013. Epub 2010 Jan 11. J Mol Biol. 2010. PMID: 20070944 Free PMC article.
Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum.
Holmes MA, Buckner FS, Van Voorhis WC, Mehlin C, Boni E, Earnest TN, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Zucker F, Schoenfeld LW, Hol WG, Merritt EA. Holmes MA, et al. Among authors: hol wg. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Mar 1;62(Pt 3):180-5. doi: 10.1107/S1744309106005847. Epub 2006 Feb 24. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16511296 Free PMC article.
The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix.
Arakaki T, Neely H, Boni E, Mueller N, Buckner FS, Van Voorhis WC, Lauricella A, DeTitta G, Luft J, Hol WG, Merritt EA. Arakaki T, et al. Among authors: hol wg. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt 3):178-82. doi: 10.1107/S1744309107007580. Epub 2007 Feb 23. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 17329808 Free PMC article.
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies.
Arakaki TL, Buckner FS, Gillespie JR, Malmquist NA, Phillips MA, Kalyuzhniy O, Luft JR, Detitta GT, Verlinde CL, Van Voorhis WC, Hol WG, Merritt EA. Arakaki TL, et al. Among authors: hol wg. Mol Microbiol. 2008 Apr;68(1):37-50. doi: 10.1111/j.1365-2958.2008.06131.x. Epub 2008 Feb 26. Mol Microbiol. 2008. PMID: 18312275 Free PMC article.
Structure of a Trypanosoma brucei alpha/beta-hydrolase fold protein with unknown function.
Merritt EA, Holmes M, Buckner FS, Van Voorhis WC, Quartly E, Phizicky EM, Lauricella A, Luft J, DeTitta G, Neely H, Zucker F, Hol WG. Merritt EA, et al. Among authors: hol wg. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt 6):474-8. doi: 10.1107/S174430910801141X. Epub 2008 May 16. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008. PMID: 18540054 Free PMC article.
Structural genomics of pathogenic protozoa: an overview.
Fan E, Baker D, Fields S, Gelb MH, Buckner FS, Van Voorhis WC, Phizicky E, Dumont M, Mehlin C, Grayhack E, Sullivan M, Verlinde C, Detitta G, Meldrum DR, Merritt EA, Earnest T, Soltis M, Zucker F, Myler PJ, Schoenfeld L, Kim D, Worthey L, Lacount D, Vignali M, Li J, Mondal S, Massey A, Carroll B, Gulde S, Luft J, Desoto L, Holl M, Caruthers J, Bosch J, Robien M, Arakaki T, Holmes M, Le Trong I, Hol WG. Fan E, et al. Among authors: hol wg. Methods Mol Biol. 2008;426:497-513. doi: 10.1007/978-1-60327-058-8_33. Methods Mol Biol. 2008. PMID: 18542886 Review.
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
Larson ET, Deng W, Krumm BE, Napuli A, Mueller N, Van Voorhis WC, Buckner FS, Fan E, Lauricella A, DeTitta G, Luft J, Zucker F, Hol WG, Verlinde CL, Merritt EA. Larson ET, et al. Among authors: hol wg. J Mol Biol. 2008 Sep 12;381(4):975-88. doi: 10.1016/j.jmb.2008.06.048. Epub 2008 Jun 24. J Mol Biol. 2008. PMID: 18602399 Free PMC article.
Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica.
Merritt EA, Arakaki TL, Larson ET, Kelley A, Mueller N, Napuli AJ, Zhang L, Deditta G, Luft J, Verlinde CL, Fan E, Zucker F, Buckner FS, Van Voorhis WC, Hol WG. Merritt EA, et al. Among authors: hol wg. Mol Biochem Parasitol. 2010 Feb;169(2):95-100. doi: 10.1016/j.molbiopara.2009.10.005. Epub 2009 Oct 27. Mol Biochem Parasitol. 2010. PMID: 19874856 Free PMC article.
Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
Merritt EA, Arakaki TL, Gillespie JR, Larson ET, Kelley A, Mueller N, Napuli AJ, Kim J, Zhang L, Verlinde CL, Fan E, Zucker F, Buckner FS, van Voorhis WC, Hol WG. Merritt EA, et al. Among authors: hol wg. J Mol Biol. 2010 Mar 26;397(2):481-94. doi: 10.1016/j.jmb.2010.01.051. Epub 2010 Feb 2. J Mol Biol. 2010. PMID: 20132829 Free PMC article.
Prediction of protein crystallization outcome using a hybrid method.
Zucker FH, Stewart C, dela Rosa J, Kim J, Zhang L, Xiao L, Ross J, Napuli AJ, Mueller N, Castaneda LJ, Nakazawa Hewitt SR, Arakaki TL, Larson ET, Subramanian E, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Merritt EA, Hol WG. Zucker FH, et al. Among authors: hol wg. J Struct Biol. 2010 Jul;171(1):64-73. doi: 10.1016/j.jsb.2010.03.016. Epub 2010 Mar 27. J Struct Biol. 2010. PMID: 20347992 Free PMC article.
346 results