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JTV519 (K201) reduces sarcoplasmic reticulum Ca²⁺ leak and improves diastolic function in vitro in murine and human non-failing myocardium.
Sacherer M, Sedej S, Wakuła P, Wallner M, Vos MA, Kockskämper J, Stiegler P, Sereinigg M, von Lewinski D, Antoons G, Pieske BM, Heinzel FR; CONTICA investigators. Sacherer M, et al. Among authors: sedej s. Br J Pharmacol. 2012 Oct;167(3):493-504. doi: 10.1111/j.1476-5381.2012.01995.x. Br J Pharmacol. 2012. PMID: 22509897 Free PMC article.
Intracellular dyssynchrony of diastolic cytosolic [Ca²⁺] decay in ventricular cardiomyocytes in cardiac remodeling and human heart failure.
Hohendanner F, Ljubojević S, MacQuaide N, Sacherer M, Sedej S, Biesmans L, Wakula P, Platzer D, Sokolow S, Herchuelz A, Antoons G, Sipido K, Pieske B, Heinzel FR. Hohendanner F, et al. Among authors: sedej s. Circ Res. 2013 Aug 16;113(5):527-38. doi: 10.1161/CIRCRESAHA.113.300895. Epub 2013 Jul 3. Circ Res. 2013. PMID: 23825358
Subclinical abnormalities in sarcoplasmic reticulum Ca(2+) release promote eccentric myocardial remodeling and pump failure death in response to pressure overload.
Sedej S, Schmidt A, Denegri M, Walther S, Matovina M, Arnstein G, Gutschi EM, Windhager I, Ljubojević S, Negri S, Heinzel FR, Bisping E, Vos MA, Napolitano C, Priori SG, Kockskämper J, Pieske B. Sedej S, et al. J Am Coll Cardiol. 2014 Apr 22;63(15):1569-79. doi: 10.1016/j.jacc.2013.11.010. Epub 2013 Dec 4. J Am Coll Cardiol. 2014. PMID: 24315909 Free article.
Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure.
Ljubojevic S, Radulovic S, Leitinger G, Sedej S, Sacherer M, Holzer M, Winkler C, Pritz E, Mittler T, Schmidt A, Sereinigg M, Wakula P, Zissimopoulos S, Bisping E, Post H, Marsche G, Bossuyt J, Bers DM, Kockskämper J, Pieske B. Ljubojevic S, et al. Among authors: sedej s. Circulation. 2014 Jul 15;130(3):244-55. doi: 10.1161/CIRCULATIONAHA.114.008927. Epub 2014 Jun 13. Circulation. 2014. PMID: 24928680 Free PMC article.
71 results