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Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time.
Ariazi EA, Cunliffe HE, Lewis-Wambi JS, Slifker MJ, Willis AL, Ramos P, Tapia C, Kim HR, Yerrum S, Sharma CG, Nicolas E, Balagurunathan Y, Ross EA, Jordan VC. Ariazi EA, et al. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):18879-86. doi: 10.1073/pnas.1115188108. Epub 2011 Oct 19. Proc Natl Acad Sci U S A. 2011. PMID: 22011582 Free PMC article.
Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen.
Ariazi EA, Leitão A, Oprea TI, Chen B, Louis T, Bertucci AM, Sharma CG, Gill SD, Kim HR, Shupp HA, Pyle JR, Madrack A, Donato AL, Cheng D, Paige JR, Jordan VC. Ariazi EA, et al. Mol Cancer Ther. 2007 Nov;6(11):2817-27. doi: 10.1158/1535-7163.MCT-07-0312. Epub 2007 Nov 7. Mol Cancer Ther. 2007. PMID: 17989318
29 results