Straarup EM - Search Results

1

Expression of apolipoprotein B in the kidney attenuates renal lipid accumulation.

Krzystanek M, Pedersen TX, Bartels ED, Kjaehr J, Straarup EM, Nielsen LB. Krzystanek M, et al. Among authors: straarup em. J Biol Chem. 2010 Apr 2;285(14):10583-90. doi: 10.1074/jbc.M109.078006. Epub 2010 Jan 26. J Biol Chem. 2010. PMID: 20103594 Free PMC article.

2

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.

Straarup EM, Fisker N, Hedtjärn M, Lindholm MW, Rosenbohm C, Aarup V, Hansen HF, Ørum H, Hansen JB, Koch T. Straarup EM, et al. Nucleic Acids Res. 2010 Nov;38(20):7100-11. doi: 10.1093/nar/gkq457. Epub 2010 Jul 8. Nucleic Acids Res. 2010. PMID: 20615897 Free PMC article.

3

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo.

Gupta N, Fisker N, Asselin MC, Lindholm M, Rosenbohm C, Ørum H, Elmén J, Seidah NG, Straarup EM. Gupta N, et al. Among authors: straarup em. PLoS One. 2010 May 17;5(5):e10682. doi: 10.1371/journal.pone.0010682. PLoS One. 2010. PMID: 20498851 Free PMC article.

4

Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver.

Elmén J, Lindow M, Silahtaroglu A, Bak M, Christensen M, Lind-Thomsen A, Hedtjärn M, Hansen JB, Hansen HF, Straarup EM, McCullagh K, Kearney P, Kauppinen S. Elmén J, et al. Among authors: straarup em. Nucleic Acids Res. 2008 Mar;36(4):1153-62. doi: 10.1093/nar/gkm1113. Epub 2007 Dec 23. Nucleic Acids Res. 2008. PMID: 18158304 Free PMC article.

5

LNA-mediated microRNA silencing in non-human primates.

Elmén J, Lindow M, Schütz S, Lawrence M, Petri A, Obad S, Lindholm M, Hedtjärn M, Hansen HF, Berger U, Gullans S, Kearney P, Sarnow P, Straarup EM, Kauppinen S. Elmén J, et al. Among authors: straarup em. Nature. 2008 Apr 17;452(7189):896-9. doi: 10.1038/nature06783. Epub 2008 Mar 26. Nature. 2008. PMID: 18368051

6

An oil mixture with trans-10, cis-12 conjugated linoleic acid increases markers of inflammation and in vivo lipid peroxidation compared with cis-9, trans-11 conjugated linoleic acid in postmenopausal women.

Tholstrup T, Raff M, Straarup EM, Lund P, Basu S, Bruun JM. Tholstrup T, et al. Among authors: straarup em. J Nutr. 2008 Aug;138(8):1445-51. doi: 10.1093/jn/138.8.1445. J Nutr. 2008. PMID: 18641189 Free article. Clinical Trial.

7

A diet rich in conjugated linoleic acid and butter increases lipid peroxidation but does not affect atherosclerotic, inflammatory, or diabetic risk markers in healthy young men.

Raff M, Tholstrup T, Basu S, Nonboe P, Sørensen MT, Straarup EM. Raff M, et al. Among authors: straarup em. J Nutr. 2008 Mar;138(3):509-14. doi: 10.1093/jn/138.3.509. J Nutr. 2008. PMID: 18287358 Free article. Clinical Trial.

8

PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates.

Lindholm MW, Elmén J, Fisker N, Hansen HF, Persson R, Møller MR, Rosenbohm C, Ørum H, Straarup EM, Koch T. Lindholm MW, et al. Among authors: straarup em. Mol Ther. 2012 Feb;20(2):376-81. doi: 10.1038/mt.2011.260. Epub 2011 Nov 22. Mol Ther. 2012. PMID: 22108858 Free PMC article.

9

Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF.

Worm J, Stenvang J, Petri A, Frederiksen KS, Obad S, Elmén J, Hedtjärn M, Straarup EM, Hansen JB, Kauppinen S. Worm J, et al. Among authors: straarup em. Nucleic Acids Res. 2009 Sep;37(17):5784-92. doi: 10.1093/nar/gkp577. Epub 2009 Jul 13. Nucleic Acids Res. 2009. PMID: 19596814 Free PMC article.

10

Silencing of microRNA families by seed-targeting tiny LNAs.

Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, Hansen HF, Koch T, Pappin D, Hannon GJ, Kauppinen S. Obad S, et al. Among authors: straarup em. Nat Genet. 2011 Mar 20;43(4):371-8. doi: 10.1038/ng.786. Nat Genet. 2011. PMID: 21423181 Free PMC article.

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