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Fragment-based discovery of BACE1 inhibitors using functional assays.
Godemann R, Madden J, Krämer J, Smith M, Fritz U, Hesterkamp T, Barker J, Höppner S, Hallett D, Cesura A, Ebneth A, Kemp J. Godemann R, et al. Biochemistry. 2009 Nov 17;48(45):10743-51. doi: 10.1021/bi901061a. Biochemistry. 2009. PMID: 19799414
Fragment-based discovery and optimization of BACE1 inhibitors.
Madden J, Dod JR, Godemann R, Kraemer J, Smith M, Biniszkiewicz M, Hallett DJ, Barker J, Dyekjaer JD, Hesterkamp T. Madden J, et al. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5329-33. doi: 10.1016/j.bmcl.2010.06.089. Epub 2010 Jun 27. Bioorg Med Chem Lett. 2010. PMID: 20656487
Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complex.
Jnoff E, Albrecht C, Barker JJ, Barker O, Beaumont E, Bromidge S, Brookfield F, Brooks M, Bubert C, Ceska T, Corden V, Dawson G, Duclos S, Fryatt T, Genicot C, Jigorel E, Kwong J, Maghames R, Mushi I, Pike R, Sands ZA, Smith MA, Stimson CC, Courade JP. Jnoff E, et al. Among authors: smith ma. ChemMedChem. 2014 Apr;9(4):699-705. doi: 10.1002/cmdc.201300525. Epub 2014 Feb 6. ChemMedChem. 2014. PMID: 24504667
Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).
Castanedo GM, Blaquiere N, Beresini M, Bravo B, Brightbill H, Chen J, Cui HF, Eigenbrot C, Everett C, Feng J, Godemann R, Gogol E, Hymowitz S, Johnson A, Kayagaki N, Kohli PB, Knüppel K, Kraemer J, Krüger S, Loke P, McEwan P, Montalbetti C, Roberts DA, Smith M, Steinbacher S, Sujatha-Bhaskar S, Takahashi R, Wang X, Wu LC, Zhang Y, Staben ST. Castanedo GM, et al. J Med Chem. 2017 Jan 26;60(2):627-640. doi: 10.1021/acs.jmedchem.6b01363. Epub 2017 Jan 12. J Med Chem. 2017. PMID: 28005357
The CD123 antibody-drug conjugate pivekimab sunirine exerts profound activity in preclinical models of pediatric acute lymphoblastic leukemia.
Watts B, Smith CM, Evans K, Gifford AJ, Mohamed SMA, Erickson SW, Earley EJ, Neuhauser S, Stearns TM, Philip VM, Chuang JH, Zweidler-McKay PA, Lakshmikanthan S, Jocoy EL, Bult CJ, Teicher BA, Smith MA, Lock RB. Watts B, et al. Among authors: smith ma. Hemasphere. 2025 Jan 17;9(1):e70063. doi: 10.1002/hem3.70063. eCollection 2025 Jan. Hemasphere. 2025. PMID: 39830370 Free PMC article.
3,159 results