Hirai H - Search Results

1

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil.

Hirai H, Arai T, Okada M, Nishibata T, Kobayashi M, Sakai N, Imagaki K, Ohtani J, Sakai T, Yoshizumi T, Mizuarai S, Iwasawa Y, Kotani H. Hirai H, et al. Cancer Biol Ther. 2010 Apr 1;9(7):514-22. doi: 10.4161/cbt.9.7.11115. Epub 2010 Apr 1. Cancer Biol Ther. 2010. PMID: 20107315 Free article.

2

Recent advances in the development of selective small molecule inhibitors for cyclin-dependent kinases.

Hirai H, Kawanishi N, Iwasawa Y. Hirai H, et al. Curr Top Med Chem. 2005;5(2):167-79. doi: 10.2174/1568026053507688. Curr Top Med Chem. 2005. PMID: 15853645 Review.

3

Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9.

Shimamura T, Shibata J, Kurihara H, Mita T, Otsuki S, Sagara T, Hirai H, Iwasawa Y. Shimamura T, et al. Among authors: hirai h. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3751-4. doi: 10.1016/j.bmcl.2006.04.048. Epub 2006 May 6. Bioorg Med Chem Lett. 2006. PMID: 16682184

4

[Novel anti-cancer compounds targeting the cell cycle].

Hirai H, Shimomura T, Komatani H, Kotani H. Hirai H, et al. Nihon Yakurigaku Zasshi. 2009 Jan;133(1):27-31. doi: 10.1254/fpj.133.27. Nihon Yakurigaku Zasshi. 2009. PMID: 19145048 Review. Japanese. No abstract available.

5

Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor.

Mizuarai S, Yamanaka K, Itadani H, Arai T, Nishibata T, Hirai H, Kotani H. Mizuarai S, et al. Among authors: hirai h. Mol Cancer. 2009 Jun 8;8:34. doi: 10.1186/1476-4598-8-34. Mol Cancer. 2009. PMID: 19500427 Free PMC article.

6

Expression levels of p18INK4C modify the cellular efficacy of cyclin-dependent kinase inhibitors via regulation of Mcl-1 expression in tumor cell lines.

Eguchi T, Itadani H, Shimomura T, Kawanishi N, Hirai H, Kotani H. Eguchi T, et al. Among authors: hirai h. Mol Cancer Ther. 2009 Jun;8(6):1460-72. doi: 10.1158/1535-7163.MCT-08-1159. Epub 2009 Jun 9. Mol Cancer Ther. 2009. PMID: 19509251

7

Expression levels of NF-Y target genes changed by CDKN1B correlate with clinical prognosis in multiple cancers.

Yamanaka K, Mizuarai S, Eguchi T, Itadani H, Hirai H, Kotani H. Yamanaka K, et al. Among authors: hirai h. Genomics. 2009 Oct;94(4):219-27. doi: 10.1016/j.ygeno.2009.06.003. Epub 2009 Jun 25. Genomics. 2009. PMID: 19559782 Free article.

8

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents.

Hirai H, Iwasawa Y, Okada M, Arai T, Nishibata T, Kobayashi M, Kimura T, Kaneko N, Ohtani J, Yamanaka K, Itadani H, Takahashi-Suzuki I, Fukasawa K, Oki H, Nambu T, Jiang J, Sakai T, Arakawa H, Sakamoto T, Sagara T, Yoshizumi T, Mizuarai S, Kotani H. Hirai H, et al. Mol Cancer Ther. 2009 Nov;8(11):2992-3000. doi: 10.1158/1535-7163.MCT-09-0463. Epub 2009 Nov 3. Mol Cancer Ther. 2009. PMID: 19887545

9

Potent anti-tumor activity of a macrocycle-quinoxalinone class pan-Cdk inhibitor in vitro and in vivo.

Hirai H, Takahashi-Suziki I, Shimomura T, Fukasawa K, Machida T, Takaki T, Kobayashi M, Eguchi T, Oki H, Arai T, Ichikawa K, Hasako S, Kodera T, Kawanishi N, Nakatsuru Y, Kotani H, Iwasawa Y. Hirai H, et al. Invest New Drugs. 2011 Aug;29(4):534-43. doi: 10.1007/s10637-009-9384-8. Epub 2010 Jan 19. Invest New Drugs. 2011. PMID: 20084424

10

Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo.

Hirai H, Shimomura T, Kobayashi M, Eguchi T, Taniguchi E, Fukasawa K, Machida T, Oki H, Arai T, Ichikawa K, Hasako S, Haze K, Kodera T, Kawanishi N, Takahashi-Suziki I, Nakatsuru Y, Kotani H, Iwasawa Y. Hirai H, et al. Cell Cycle. 2010 Apr 15;9(8):1590-600. doi: 10.4161/cc.9.8.11306. Epub 2010 Apr 15. Cell Cycle. 2010. PMID: 20372067

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