Donato NJ - Search Results

1

ON012380, a putative BCR-ABL kinase inhibitor with a unique mechanism of action in imatinib-resistant cells.

Wu J, Meng F, Ying Y, Peng Z, Daniels L, Bornmann WG, Quintás-Cardama A, Roulston D, Talpaz M, Peterson LF, Donato NJ. Wu J, et al. Among authors: donato nj. Leukemia. 2010 Apr;24(4):869-72. doi: 10.1038/leu.2009.300. Epub 2010 Jan 28. Leukemia. 2010. PMID: 20111070 Free PMC article. No abstract available.

2

Sequencing of subcloned PCR products facilitates earlier detection of BCR-ABL1(T315I) and other mutants compared to direct sequencing of the ABL1 kinase domain.

Quintás-Cardama A, Gibbons DL, Kantarjian H, Talpaz M, Donato N, Cortes J. Quintás-Cardama A, et al. Leukemia. 2008 Apr;22(4):885-8. doi: 10.1038/leu.2008.42. Epub 2008 Feb 28. Leukemia. 2008. PMID: 18305550 No abstract available.

3

Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase.

Wu J, Meng F, Kong LY, Peng Z, Ying Y, Bornmann WG, Darnay BG, Lamothe B, Sun H, Talpaz M, Donato NJ. Wu J, et al. Among authors: donato nj. J Natl Cancer Inst. 2008 Jul 2;100(13):926-39. doi: 10.1093/jnci/djn188. Epub 2008 Jun 24. J Natl Cancer Inst. 2008. PMID: 18577747 Free PMC article.

4

Chronic myeloid leukemia stem cells and developing therapies.

Donato NJ, Peterson LF. Donato NJ, et al. Leuk Lymphoma. 2011 Feb;52 Suppl 1:60-80. doi: 10.3109/10428194.2010.546921. Leuk Lymphoma. 2011. PMID: 21299460 Review.

5

Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.

Wu J, Meng F, Lu H, Kong L, Bornmann W, Peng Z, Talpaz M, Donato NJ. Wu J, et al. Among authors: donato nj. Blood. 2008 Apr 1;111(7):3821-9. doi: 10.1182/blood-2007-08-109330. Epub 2008 Jan 30. Blood. 2008. PMID: 18235045 Free PMC article.

6

Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.

Sun H, Kapuria V, Peterson LF, Fang D, Bornmann WG, Bartholomeusz G, Talpaz M, Donato NJ. Sun H, et al. Among authors: donato nj. Blood. 2011 Mar 17;117(11):3151-62. doi: 10.1182/blood-2010-03-276477. Epub 2011 Jan 19. Blood. 2011. PMID: 21248063 Free article.

7

Imatinib mesylate suppresses cytokine synthesis by activated CD4 T cells of patients with chronic myelogenous leukemia.

Gao H, Lee BN, Talpaz M, Donato NJ, Cortes JE, Kantarjian HM, Reuben JM. Gao H, et al. Among authors: donato nj. Leukemia. 2005 Nov;19(11):1905-11. doi: 10.1038/sj.leu.2403933. Leukemia. 2005. PMID: 16151467

8

p53 stabilization induces apoptosis in chronic myeloid leukemia blast crisis cells.

Peterson LF, Mitrikeska E, Giannola D, Lui Y, Sun H, Bixby D, Malek SN, Donato NJ, Wang S, Talpaz M. Peterson LF, et al. Among authors: donato nj. Leukemia. 2011 May;25(5):761-9. doi: 10.1038/leu.2011.7. Epub 2011 Feb 25. Leukemia. 2011. PMID: 21350558

9

Molecular dynamics reveal BCR-ABL1 polymutants as a unique mechanism of resistance to PAN-BCR-ABL1 kinase inhibitor therapy.

Gibbons DL, Pricl S, Posocco P, Laurini E, Fermeglia M, Sun H, Talpaz M, Donato N, Quintás-Cardama A. Gibbons DL, et al. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3550-5. doi: 10.1073/pnas.1321173111. Epub 2014 Feb 18. Proc Natl Acad Sci U S A. 2014. PMID: 24550512 Free PMC article.

10

Targets and effectors of the cellular response to aurora kinase inhibitor MK-0457 (VX-680) in imatinib sensitive and resistant chronic myelogenous leukemia.

Donato NJ, Fang D, Sun H, Giannola D, Peterson LF, Talpaz M. Donato NJ, et al. Biochem Pharmacol. 2010 Mar 1;79(5):688-97. doi: 10.1016/j.bcp.2009.10.009. Epub 2009 Oct 27. Biochem Pharmacol. 2010. PMID: 19874801

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