Chiosis G - Search Results

1

Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab.

Holland JP, Caldas-Lopes E, Divilov V, Longo VA, Taldone T, Zatorska D, Chiosis G, Lewis JS. Holland JP, et al. Among authors: chiosis g. PLoS One. 2010 Jan 25;5(1):e8859. doi: 10.1371/journal.pone.0008859. PLoS One. 2010. PMID: 20111600 Free PMC article.

2

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase.

Chiosis G, Lucas B, Shtil A, Huezo H, Rosen N. Chiosis G, et al. Bioorg Med Chem. 2002 Nov;10(11):3555-64. doi: 10.1016/s0968-0896(02)00253-5. Bioorg Med Chem. 2002. PMID: 12213470

3

Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.

Llauger-Bufi L, Felts SJ, Huezo H, Rosen N, Chiosis G. Llauger-Bufi L, et al. Among authors: chiosis g. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3975-8. doi: 10.1016/j.bmcl.2003.08.065. Bioorg Med Chem Lett. 2003. PMID: 14592488

4

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

Vilenchik M, Solit D, Basso A, Huezo H, Lucas B, He H, Rosen N, Spampinato C, Modrich P, Chiosis G. Vilenchik M, et al. Among authors: chiosis g. Chem Biol. 2004 Jun;11(6):787-97. doi: 10.1016/j.chembiol.2004.04.008. Chem Biol. 2004. PMID: 15217612

5

Hsp90: the vulnerable chaperone.

Chiosis G, Vilenchik M, Kim J, Solit D. Chiosis G, et al. Drug Discov Today. 2004 Oct 15;9(20):881-8. doi: 10.1016/S1359-6446(04)03245-3. Drug Discov Today. 2004. PMID: 15475321 Review.

6

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

He H, Zatorska D, Kim J, Aguirre J, Llauger L, She Y, Wu N, Immormino RM, Gewirth DT, Chiosis G. He H, et al. Among authors: chiosis g. J Med Chem. 2006 Jan 12;49(1):381-90. doi: 10.1021/jm0508078. J Med Chem. 2006. PMID: 16392823

7

Synthesis of Hsp90 dimerization modulators.

Chiosis G, Aguirre J, Nicchitta CV. Chiosis G, et al. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3529-32. doi: 10.1016/j.bmcl.2006.03.092. Epub 2006 Apr 18. Bioorg Med Chem Lett. 2006. PMID: 16621545

8

Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents.

Chiosis G, Caldas Lopes E, Solit D. Chiosis G, et al. Curr Opin Investig Drugs. 2006 Jun;7(6):534-41. Curr Opin Investig Drugs. 2006. PMID: 16784024 Review.

9

Purine-scaffold Hsp90 inhibitors.

Chiosis G, Tao H. Chiosis G, et al. IDrugs. 2006 Nov;9(11):778-82. IDrugs. 2006. PMID: 17096299

10

Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive.

Chiosis G, Neckers L. Chiosis G, et al. ACS Chem Biol. 2006 Jun 20;1(5):279-84. doi: 10.1021/cb600224w. ACS Chem Biol. 2006. PMID: 17163756 Review.

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