Diederich WE - Search Results

1

Pyrrolidine derivatives as plasmepsin inhibitors: binding mode analysis assisted by molecular dynamics simulations of a highly flexible protein.

Luksch T, Blum A, Klee N, Diederich WE, Sotriffer CA, Klebe G. Luksch T, et al. Among authors: diederich we. ChemMedChem. 2010 Mar 1;5(3):443-54. doi: 10.1002/cmdc.200900452. ChemMedChem. 2010. PMID: 20112327

2

DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer.

Brichkina A, Ems M, Suezov R, Singh R, Lutz V, Picard FSR, Nist A, Stiewe T, Graumann J, Daude M, Diederich WE, Finkernagel F, Chung HR, Bartsch DK, Roth K, Keber C, Denkert C, Huber M, Gress TM, Lauth M. Brichkina A, et al. Among authors: diederich we. Gut. 2024 Sep 9;73(10):1684-1701. doi: 10.1136/gutjnl-2023-331854. Gut. 2024. PMID: 38834297 Free PMC article.

3

Tumor-suppressive disruption of cancer subtype-associated super enhancer circuits by small molecule treatment.

Koeniger A, Polo P, Brichkina A, Finkernagel F, Visekruna A, Nist A, Stiewe T, Daude M, Diederich WE, Gress TM, Adhikary T, Lauth M. Koeniger A, et al. Among authors: diederich we. NAR Cancer. 2023 Feb 6;5(1):zcad007. doi: 10.1093/narcan/zcad007. eCollection 2023 Mar. NAR Cancer. 2023. PMID: 36755960 Free PMC article.

4

KNOBLE: a knowledge-based approach for the design and synthesis of readily accessible small-molecule chemical probes to test protein binding.

Gerlach C, Münzel M, Baum B, Gerber HD, Craan T, Diederich WE, Klebe G. Gerlach C, et al. Among authors: diederich we. Angew Chem Int Ed Engl. 2007;46(47):9105-9. doi: 10.1002/anie.200703323. Angew Chem Int Ed Engl. 2007. PMID: 17955562 No abstract available.

5

Structure-guided design of C2-symmetric HIV-1 protease inhibitors based on a pyrrolidine scaffold.

Blum A, Böttcher J, Heine A, Klebe G, Diederich WE. Blum A, et al. Among authors: diederich we. J Med Chem. 2008 Apr 10;51(7):2078-87. doi: 10.1021/jm701142s. Epub 2008 Mar 19. J Med Chem. 2008. PMID: 18348517

6

Structural and kinetic analysis of pyrrolidine-based inhibitors of the drug-resistant Ile84Val mutant of HIV-1 protease.

Böttcher J, Blum A, Heine A, Diederich WE, Klebe G. Böttcher J, et al. Among authors: diederich we. J Mol Biol. 2008 Nov 7;383(2):347-57. doi: 10.1016/j.jmb.2008.07.062. Epub 2008 Jul 29. J Mol Biol. 2008. PMID: 18692068

7

Targeting the open-flap conformation of HIV-1 protease with pyrrolidine-based inhibitors.

Böttcher J, Blum A, Dörr S, Heine A, Diederich WE, Klebe G. Böttcher J, et al. Among authors: diederich we. ChemMedChem. 2008 Sep;3(9):1337-44. doi: 10.1002/cmdc.200800113. ChemMedChem. 2008. PMID: 18720485

8

Computer-aided design and synthesis of nonpeptidic plasmepsin II and IV inhibitors.

Luksch T, Chan NS, Brass S, Sotriffer CA, Klebe G, Diederich WE. Luksch T, et al. Among authors: diederich we. ChemMedChem. 2008 Sep;3(9):1323-36. doi: 10.1002/cmdc.200700270. ChemMedChem. 2008. PMID: 18752222

9

Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors.

Blum A, Böttcher J, Sammet B, Luksch T, Heine A, Klebe G, Diederich WE. Blum A, et al. Among authors: diederich we. Bioorg Med Chem. 2008 Sep 15;16(18):8574-86. doi: 10.1016/j.bmc.2008.08.012. Epub 2008 Aug 7. Bioorg Med Chem. 2008. PMID: 18760609

10

Fragment-based lead discovery: screening and optimizing fragments for thermolysin inhibition.

Englert L, Silber K, Steuber H, Brass S, Over B, Gerber HD, Heine A, Diederich WE, Klebe G. Englert L, et al. Among authors: diederich we. ChemMedChem. 2010 Jun 7;5(6):930-40. doi: 10.1002/cmdc.201000084. ChemMedChem. 2010. PMID: 20394106

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