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XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice.
Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, Fox E, Bronson R, De Girolami U, Lee C, Alt FW. Yan CT, et al. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7378-83. doi: 10.1073/pnas.0601938103. Epub 2006 May 2. Proc Natl Acad Sci U S A. 2006. PMID: 16670198 Free PMC article.
Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome.
Rucci F, Notarangelo LD, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley KM, Detre C, Keszei M, Walter JE, Feldman L, Cheng HL, Poliani PL, Wang JH, Balter BB, Recher M, Andersson EM, Zha S, Giliani S, Terhorst C, Alt FW, Yan CT. Rucci F, et al. Among authors: yan ct. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3024-9. doi: 10.1073/pnas.0914865107. Epub 2010 Feb 1. Proc Natl Acad Sci U S A. 2010. PMID: 20133615 Free PMC article.
Mechanisms promoting translocations in editing and switching peripheral B cells.
Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. Wang JH, et al. Among authors: yan ct. Nature. 2009 Jul 9;460(7252):231-6. doi: 10.1038/nature08159. Nature. 2009. PMID: 19587764 Free PMC article.
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.
Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW. Franco S, et al. Mol Cell. 2006 Jan 20;21(2):201-14. doi: 10.1016/j.molcel.2006.01.005. Mol Cell. 2006. PMID: 16427010 Free article.
45 results