Dexheimer TS - Search Results

1

Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors.

Song Y, Shao Z, Dexheimer TS, Scher ES, Pommier Y, Cushman M. Song Y, et al. Among authors: dexheimer ts. J Med Chem. 2010 Mar 11;53(5):1979-89. doi: 10.1021/jm901649x. J Med Chem. 2010. PMID: 20155916 Free PMC article.

2

Conformationally restricted analogues of psorospermin: design, synthesis, and bioactivity of natural-product-related bisfuranoxanthones.

Heald RA, Dexheimer TS, Vankayalapati H, Siddiqui-Jain A, Szabo LZ, Gleason-Guzman MC, Hurley LH. Heald RA, et al. Among authors: dexheimer ts. J Med Chem. 2005 Apr 21;48(8):2993-3004. doi: 10.1021/jm049299c. J Med Chem. 2005. PMID: 15828838

3

Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization.

Morrell A, Placzek M, Parmley S, Antony S, Dexheimer TS, Pommier Y, Cushman M. Morrell A, et al. Among authors: dexheimer ts. J Med Chem. 2007 Sep 6;50(18):4419-30. doi: 10.1021/jm070361q. Epub 2007 Aug 15. J Med Chem. 2007. PMID: 17696418

4

Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters.

Takagi K, Dexheimer TS, Redon C, Sordet O, Agama K, Lavielle G, Pierré A, Bates SE, Pommier Y. Takagi K, et al. Among authors: dexheimer ts. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3229-38. doi: 10.1158/1535-7163.MCT-07-0441. Mol Cancer Ther. 2007. PMID: 18089716

5

Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.

Dexheimer TS, Antony S, Marchand C, Pommier Y. Dexheimer TS, et al. Anticancer Agents Med Chem. 2008 May;8(4):381-9. doi: 10.2174/187152008784220357. Anticancer Agents Med Chem. 2008. PMID: 18473723 Free PMC article. Review.

6

The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts.

Dexheimer TS, Kozekova A, Rizzo CJ, Stone MP, Pommier Y. Dexheimer TS, et al. Nucleic Acids Res. 2008 Jul;36(12):4128-36. doi: 10.1093/nar/gkn334. Epub 2008 Jun 10. Nucleic Acids Res. 2008. PMID: 18550580 Free PMC article.

7

Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.

Cinelli MA, Morrell A, Dexheimer TS, Scher ES, Pommier Y, Cushman M. Cinelli MA, et al. Among authors: dexheimer ts. J Med Chem. 2008 Aug 14;51(15):4609-19. doi: 10.1021/jm800259e. Epub 2008 Jul 17. J Med Chem. 2008. PMID: 18630891 Free PMC article.

8

Par-4 binds to topoisomerase 1 and attenuates its DNA relaxation activity.

Goswami A, Qiu S, Dexheimer TS, Ranganathan P, Burikhanov R, Pommier Y, Rangnekar VM. Goswami A, et al. Among authors: dexheimer ts. Cancer Res. 2008 Aug 1;68(15):6190-8. doi: 10.1158/0008-5472.CAN-08-0831. Cancer Res. 2008. PMID: 18676842 Free PMC article.

9

DNA cleavage assay for the identification of topoisomerase I inhibitors.

Dexheimer TS, Pommier Y. Dexheimer TS, et al. Nat Protoc. 2008;3(11):1736-50. doi: 10.1038/nprot.2008.174. Nat Protoc. 2008. PMID: 18927559 Free PMC article.

10

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay.

Marchand C, Lea WA, Jadhav A, Dexheimer TS, Austin CP, Inglese J, Pommier Y, Simeonov A. Marchand C, et al. Among authors: dexheimer ts. Mol Cancer Ther. 2009 Jan;8(1):240-8. doi: 10.1158/1535-7163.MCT-08-0878. Mol Cancer Ther. 2009. PMID: 19139134 Free PMC article.

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