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Page 1
Molecular mechanism of the sweet taste enhancers.
Zhang F, Klebansky B, Fine RM, Liu H, Xu H, Servant G, Zoller M, Tachdjian C, Li X. Zhang F, et al. Among authors: klebansky b. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4752-7. doi: 10.1073/pnas.0911660107. Epub 2010 Feb 19. Proc Natl Acad Sci U S A. 2010. PMID: 20173095 Free PMC article.
Molecular mechanism for the umami taste synergism.
Zhang F, Klebansky B, Fine RM, Xu H, Pronin A, Liu H, Tachdjian C, Li X. Zhang F, et al. Among authors: klebansky b. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20930-4. doi: 10.1073/pnas.0810174106. Epub 2008 Dec 22. Proc Natl Acad Sci U S A. 2008. PMID: 19104071 Free PMC article.
Inhibitors of ABL and the ABL-T315I mutation.
Noronha G, Cao J, Chow CP, Dneprovskaia E, Fine RM, Hood J, Kang X, Klebansky B, Lohse D, Mak CC, McPherson A, Palanki MS, Pathak VP, Renick J, Soll R, Zeng B. Noronha G, et al. Among authors: klebansky b. Curr Top Med Chem. 2008;8(10):905-21. doi: 10.2174/156802608784911635. Curr Top Med Chem. 2008. PMID: 18673174
The design and preliminary structure-activity relationship studies of benzotriazines as potent inhibitors of Abl and Abl-T315I enzymes.
Cao J, Fine R, Gritzen C, Hood J, Kang X, Klebansky B, Lohse D, Mak CC, McPherson A, Noronha G, Palanki MS, Pathak VP, Renick J, Soll R, Zeng B, Zhu H. Cao J, et al. Among authors: klebansky b. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5812-8. doi: 10.1016/j.bmcl.2007.08.043. Epub 2007 Aug 25. Bioorg Med Chem Lett. 2007. PMID: 17827012
Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl benzoate (TG100801): a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration.
Palanki MS, Akiyama H, Campochiaro P, Cao J, Chow CP, Dellamary L, Doukas J, Fine R, Gritzen C, Hood JD, Hu S, Kachi S, Kang X, Klebansky B, Kousba A, Lohse D, Mak CC, Martin M, McPherson A, Pathak VP, Renick J, Soll R, Umeda N, Yee S, Yokoi K, Zeng B, Zhu H, Noronha G. Palanki MS, et al. Among authors: klebansky b. J Med Chem. 2008 Mar 27;51(6):1546-59. doi: 10.1021/jm7011276. Epub 2008 Feb 27. J Med Chem. 2008. PMID: 18311895
Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors.
Noronha G, Barrett K, Cao J, Dneprovskaia E, Fine R, Gong X, Gritzen C, Hood J, Kang X, Klebansky B, Li G, Liao W, Lohse D, Mak CC, McPherson A, Palanki MS, Pathak VP, Renick J, Soll R, Splittgerber U, Wrasidlo W, Zeng B, Zhao N, Zhou Y. Noronha G, et al. Among authors: klebansky b. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5546-50. doi: 10.1016/j.bmcl.2006.08.035. Epub 2006 Aug 22. Bioorg Med Chem Lett. 2006. PMID: 16931012
Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays.
Noronha G, Barrett K, Boccia A, Brodhag T, Cao J, Chow CP, Dneprovskaia E, Doukas J, Fine R, Gong X, Gritzen C, Gu H, Hanna E, Hood JD, Hu S, Kang X, Key J, Klebansky B, Kousba A, Li G, Lohse D, Mak CC, McPherson A, Palanki MS, Pathak VP, Renick J, Shi F, Soll R, Splittgerber U, Stoughton S, Tang S, Yee S, Zeng B, Zhao N, Zhu H. Noronha G, et al. Among authors: klebansky b. Bioorg Med Chem Lett. 2007 Feb 1;17(3):602-8. doi: 10.1016/j.bmcl.2006.11.006. Epub 2006 Nov 7. Bioorg Med Chem Lett. 2007. PMID: 17113292
A novel steroidal inhibitor of estrogen-related receptor alpha (ERR alpha).
Duellman SJ, Calaoagan JM, Sato BG, Fine R, Klebansky B, Chao WR, Hobbs P, Collins N, Sambucetti L, Laderoute KR. Duellman SJ, et al. Among authors: klebansky b. Biochem Pharmacol. 2010 Sep 15;80(6):819-26. doi: 10.1016/j.bcp.2010.05.024. Epub 2010 May 31. Biochem Pharmacol. 2010. PMID: 20513360 Free PMC article.
Kokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus).
Laffitte A, Gibbs M, Hernangomez de Alvaro C, Addison J, Lonsdale ZN, Giribaldi MG, Rossignoli A, Vennegeerts T, Winnig M, Klebansky B, Skiles J, Logan DW, McGrane SJ. Laffitte A, et al. Among authors: klebansky b. Sci Rep. 2021 May 18;11(1):10527. doi: 10.1038/s41598-021-89558-w. Sci Rep. 2021. PMID: 34006911 Free PMC article.
13 results