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Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity.
Coolen MW, Stirzaker C, Song JZ, Statham AL, Kassir Z, Moreno CS, Young AN, Varma V, Speed TP, Cowley M, Lacaze P, Kaplan W, Robinson MD, Clark SJ. Coolen MW, et al. Among authors: lacaze p. Nat Cell Biol. 2010 Mar;12(3):235-46. doi: 10.1038/ncb2023. Epub 2010 Feb 21. Nat Cell Biol. 2010. PMID: 20173741 Free PMC article.
ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype.
Junankar S, Baker LA, Roden DL, Nair R, Elsworth B, Gallego-Ortega D, Lacaze P, Cazet A, Nikolic I, Teo WS, Yang J, McFarland A, Harvey K, Naylor MJ, Lakhani SR, Simpson PT, Raghavendra A, Saunus J, Madore J, Kaplan W, Ormandy C, Millar EK, O'Toole S, Yun K, Swarbrick A. Junankar S, et al. Among authors: lacaze p. Nat Commun. 2015 Mar 27;6:6548. doi: 10.1038/ncomms7548. Nat Commun. 2015. PMID: 25813983 Free article.
The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly.
Pinese M, Lacaze P, Rath EM, Stone A, Brion MJ, Ameur A, Nagpal S, Puttick C, Husson S, Degrave D, Cristina TN, Kahl VFS, Statham AL, Woods RL, McNeil JJ, Riaz M, Barr M, Nelson MR, Reid CM, Murray AM, Shah RC, Wolfe R, Atkins JR, Fitzsimmons C, Cairns HM, Green MJ, Carr VJ, Cowley MJ, Pickett HA, James PA, Powell JE, Kaplan W, Gibson G, Gyllensten U, Cairns MJ, McNamara M, Dinger ME, Thomas DM. Pinese M, et al. Among authors: lacaze p. Nat Commun. 2020 Jan 23;11(1):435. doi: 10.1038/s41467-019-14079-0. Nat Commun. 2020. PMID: 31974348 Free PMC article.
Rare disease registries: a call to action.
Lacaze P, Millis N, Fookes M, Zurynski Y, Jaffe A, Bellgard M, Winship I, McNeil J, Bittles AH. Lacaze P, et al. Intern Med J. 2017 Sep;47(9):1075-1079. doi: 10.1111/imj.13528. Intern Med J. 2017. PMID: 28891182
Implementation of public health genomics in Pakistan.
Riaz M, Tiller J, Ajmal M, Azam M, Qamar R, Lacaze P. Riaz M, et al. Among authors: lacaze p. Eur J Hum Genet. 2019 Oct;27(10):1485-1492. doi: 10.1038/s41431-019-0428-z. Epub 2019 May 17. Eur J Hum Genet. 2019. PMID: 31101884 Free PMC article. Review.
Response to Veenstra et al.
Lacaze P, Tiller J, Bao Y, Riaz M, Winship I, Zhang L. Lacaze P, et al. Genet Med. 2019 Dec;21(12):2842-2843. doi: 10.1038/s41436-019-0581-3. Epub 2019 Jul 15. Genet Med. 2019. PMID: 31303646 Free article. No abstract available.
133 results