Holloway MK - Search Results

1

SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition.

Rajapakse HA, Nantermet PG, Selnick HG, Barrow JC, McGaughey GB, Munshi S, Lindsley SR, Young MB, Ngo PL, Holloway MK, Lai MT, Espeseth AS, Shi XP, Colussi D, Pietrak B, Crouthamel MC, Tugusheva K, Huang Q, Xu M, Simon AJ, Kuo L, Hazuda DJ, Graham S, Vacca JP. Rajapakse HA, et al. Among authors: holloway mk. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1885-9. doi: 10.1016/j.bmcl.2010.01.137. Epub 2010 Feb 4. Bioorg Med Chem Lett. 2010. PMID: 20176482

2

Synthesis, antiviral activity, and bioavailability studies of gamma-lactam derived HIV protease inhibitors.

Hungate RW, Chen JL, Starbuck KE, Vacca JP, McDaniel SL, Levin RB, Dorsey BD, Guare JP, Holloway MK, Whitter W, et al. Hungate RW, et al. Among authors: holloway mk. Bioorg Med Chem. 1994 Sep;2(9):859-79. doi: 10.1016/s0968-0896(00)82037-4. Bioorg Med Chem. 1994. PMID: 7712123

3

4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.

Wai JS, Egbertson MS, Payne LS, Fisher TE, Embrey MW, Tran LO, Melamed JY, Langford HM, Guare JP Jr, Zhuang L, Grey VE, Vacca JP, Holloway MK, Naylor-Olsen AM, Hazuda DJ, Felock PJ, Wolfe AL, Stillmock KA, Schleif WA, Gabryelski LJ, Young SD. Wai JS, et al. Among authors: holloway mk. J Med Chem. 2000 Dec 28;43(26):4923-6. doi: 10.1021/jm000176b. J Med Chem. 2000. PMID: 11150161 No abstract available.

4

A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site.

Holloway MK, Wai JM, Halgren TA, Fitzgerald PM, Vacca JP, Dorsey BD, Levin RB, Thompson WJ, Chen LJ, deSolms SJ. Holloway MK, et al. J Med Chem. 1995 Jan 20;38(2):305-17. doi: 10.1021/jm00002a012. J Med Chem. 1995. PMID: 7830273

5

Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors.

Dorsey BD, McDonough C, McDaniel SL, Levin RB, Newton CL, Hoffman JM, Darke PL, Zugay-Murphy JA, Emini EA, Schleif WA, Olsen DB, Stahlhut MW, Rutkowski CA, Kuo LC, Lin JH, Chen IW, Michelson SR, Holloway MK, Huff JR, Vacca JP. Dorsey BD, et al. Among authors: holloway mk. J Med Chem. 2000 Sep 7;43(18):3386-99. doi: 10.1021/jm9903848. J Med Chem. 2000. PMID: 10978186

6

MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease.

Liverton NJ, Carroll SS, Dimuzio J, Fandozzi C, Graham DJ, Hazuda D, Holloway MK, Ludmerer SW, McCauley JA, McIntyre CJ, Olsen DB, Rudd MT, Stahlhut M, Vacca JP. Liverton NJ, et al. Among authors: holloway mk. Antimicrob Agents Chemother. 2010 Jan;54(1):305-11. doi: 10.1128/AAC.00677-09. Epub 2009 Oct 19. Antimicrob Agents Chemother. 2010. PMID: 19841155 Free PMC article.

7

Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics.

Williams PD, Perlow DS, Payne LS, Holloway MK, Siegl PK, Schorn TW, Lynch RJ, Doyle JJ, Strouse JF, Vlasuk GP, et al. Williams PD, et al. Among authors: holloway mk. J Med Chem. 1991 Mar;34(3):887-900. doi: 10.1021/jm00107a004. J Med Chem. 1991. PMID: 2002469

8

The development of cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors.

Ghosh AK, Lee HY, Thompson WJ, Culberson C, Holloway MK, McKee SP, Munson PM, Duong TT, Smith AM, Darke PL, et al. Ghosh AK, et al. Among authors: holloway mk. J Med Chem. 1994 Apr 15;37(8):1177-88. doi: 10.1021/jm00034a016. J Med Chem. 1994. PMID: 8164260

9

Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents: X-ray crystal structure assisted design.

Thompson WJ, Fitzgerald PM, Holloway MK, Emini EA, Darke PL, McKeever BM, Schleif WA, Quintero JC, Zugay JA, Tucker TJ, et al. Thompson WJ, et al. Among authors: holloway mk. J Med Chem. 1992 May 15;35(10):1685-701. doi: 10.1021/jm00088a003. J Med Chem. 1992. PMID: 1588551

10

An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex.

Smith AB 3rd, Hirschmann R, Pasternak A, Yao W, Sprengeler PA, Holloway MK, Kuo LC, Chen Z, Darke PL, Schleif WA. Smith AB 3rd, et al. Among authors: holloway mk. J Med Chem. 1997 Aug 1;40(16):2440-4. doi: 10.1021/jm970195u. J Med Chem. 1997. PMID: 9258349 No abstract available.

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