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Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.
Nuti E, Casalini F, Avramova SI, Santamaria S, Fabbi M, Ferrini S, Marinelli L, La Pietra V, Limongelli V, Novellino E, Cercignani G, Orlandini E, Nencetti S, Rossello A. Nuti E, et al. Among authors: cercignani g. J Med Chem. 2010 Mar 25;53(6):2622-35. doi: 10.1021/jm901868z. J Med Chem. 2010. PMID: 20180536
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
Nuti E, Casalini F, Avramova SI, Santamaria S, Cercignani G, Marinelli L, La Pietra V, Novellino E, Orlandini E, Nencetti S, Tuccinardi T, Martinelli A, Lim NH, Visse R, Nagase H, Rossello A. Nuti E, et al. Among authors: cercignani g. J Med Chem. 2009 Aug 13;52(15):4757-73. doi: 10.1021/jm900261f. J Med Chem. 2009. PMID: 19606871
Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors.
Nuti E, Panelli L, Casalini F, Avramova SI, Orlandini E, Santamaria S, Nencetti S, Tuccinardi T, Martinelli A, Cercignani G, D'Amelio N, Maiocchi A, Uggeri F, Rossello A. Nuti E, et al. Among authors: cercignani g. J Med Chem. 2009 Oct 22;52(20):6347-61. doi: 10.1021/jm900335a. J Med Chem. 2009. PMID: 19775099
Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors.
Adekoya OA, Sjøli S, Wuxiuer Y, Bilto I, Marques SM, Santos MA, Nuti E, Cercignani G, Rossello A, Winberg JO, Sylte I. Adekoya OA, et al. Among authors: cercignani g. Eur J Med Chem. 2015 Jan 7;89:340-8. doi: 10.1016/j.ejmech.2014.10.009. Epub 2014 Oct 18. Eur J Med Chem. 2015. PMID: 25462250
48 results