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Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid.
Pohjoismäki JL, Holmes JB, Wood SR, Yang MY, Yasukawa T, Reyes A, Bailey LJ, Cluett TJ, Goffart S, Willcox S, Rigby RE, Jackson AP, Spelbrink JN, Griffith JD, Crouch RJ, Jacobs HT, Holt IJ. Pohjoismäki JL, et al. Among authors: crouch rj. J Mol Biol. 2010 Apr 16;397(5):1144-55. doi: 10.1016/j.jmb.2010.02.029. Epub 2010 Feb 23. J Mol Biol. 2010. PMID: 20184890 Free PMC article.
Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria.
Akman G, Desai R, Bailey LJ, Yasukawa T, Dalla Rosa I, Durigon R, Holmes JB, Moss CF, Mennuni M, Houlden H, Crouch RJ, Hanna MG, Pitceathly RD, Spinazzola A, Holt IJ. Akman G, et al. Among authors: crouch rj. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4276-85. doi: 10.1073/pnas.1600537113. Epub 2016 Jul 8. Proc Natl Acad Sci U S A. 2016. PMID: 27402764 Free PMC article.
Actin and myosin contribute to mammalian mitochondrial DNA maintenance.
Reyes A, He J, Mao CC, Bailey LJ, Di Re M, Sembongi H, Kazak L, Dzionek K, Holmes JB, Cluett TJ, Harbour ME, Fearnley IM, Crouch RJ, Conti MA, Adelstein RS, Walker JE, Holt IJ. Reyes A, et al. Among authors: crouch rj. Nucleic Acids Res. 2011 Jul;39(12):5098-108. doi: 10.1093/nar/gkr052. Epub 2011 Mar 11. Nucleic Acids Res. 2011. PMID: 21398640 Free PMC article.
RNase H1, the Gold Standard for R-Loop Detection.
Cerritelli SM, Sakhuja K, Crouch RJ. Cerritelli SM, et al. Among authors: crouch rj. Methods Mol Biol. 2022;2528:91-114. doi: 10.1007/978-1-0716-2477-7_7. Methods Mol Biol. 2022. PMID: 35704187 Review.
95 results