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Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid.
Pohjoismäki JL, Holmes JB, Wood SR, Yang MY, Yasukawa T, Reyes A, Bailey LJ, Cluett TJ, Goffart S, Willcox S, Rigby RE, Jackson AP, Spelbrink JN, Griffith JD, Crouch RJ, Jacobs HT, Holt IJ. Pohjoismäki JL, et al. Among authors: jackson ap. J Mol Biol. 2010 Apr 16;397(5):1144-55. doi: 10.1016/j.jmb.2010.02.029. Epub 2010 Feb 23. J Mol Biol. 2010. PMID: 20184890 Free PMC article.
Nucleic acid-mediated inflammatory diseases.
Rigby RE, Leitch A, Jackson AP. Rigby RE, et al. Among authors: jackson ap. Bioessays. 2008 Sep;30(9):833-42. doi: 10.1002/bies.20808. Bioessays. 2008. PMID: 18693262 Review.
Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.
Reijns MA, Rabe B, Rigby RE, Mill P, Astell KR, Lettice LA, Boyle S, Leitch A, Keighren M, Kilanowski F, Devenney PS, Sexton D, Grimes G, Holt IJ, Hill RE, Taylor MS, Lawson KA, Dorin JR, Jackson AP. Reijns MA, et al. Among authors: jackson ap. Cell. 2012 May 25;149(5):1008-22. doi: 10.1016/j.cell.2012.04.011. Epub 2012 May 10. Cell. 2012. PMID: 22579044 Free PMC article.
RNA:DNA hybrids are a novel molecular pattern sensed by TLR9.
Rigby RE, Webb LM, Mackenzie KJ, Li Y, Leitch A, Reijns MA, Lundie RJ, Revuelta A, Davidson DJ, Diebold S, Modis Y, MacDonald AS, Jackson AP. Rigby RE, et al. Among authors: jackson ap. EMBO J. 2014 Mar 18;33(6):542-58. doi: 10.1002/embj.201386117. Epub 2014 Feb 10. EMBO J. 2014. PMID: 24514026 Free PMC article.
Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.
Mackenzie KJ, Carroll P, Lettice L, Tarnauskaitė Ž, Reddy K, Dix F, Revuelta A, Abbondati E, Rigby RE, Rabe B, Kilanowski F, Grimes G, Fluteau A, Devenney PS, Hill RE, Reijns MA, Jackson AP. Mackenzie KJ, et al. Among authors: jackson ap. EMBO J. 2016 Apr 15;35(8):831-44. doi: 10.15252/embj.201593339. Epub 2016 Feb 22. EMBO J. 2016. PMID: 26903602 Free PMC article.
Replication proteins and human disease.
Jackson AP, Laskey RA, Coleman N. Jackson AP, et al. Cold Spring Harb Perspect Biol. 2014 Jan 1;6(1):a013060. doi: 10.1101/cshperspect.a013060. Cold Spring Harb Perspect Biol. 2014. PMID: 23881941 Free PMC article. Review.
Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis.
Bellelli R, Borel V, Logan C, Svendsen J, Cox DE, Nye E, Metcalfe K, O'Connell SM, Stamp G, Flynn HR, Snijders AP, Lassailly F, Jackson A, Boulton SJ. Bellelli R, et al. Among authors: jackson a. Mol Cell. 2018 May 17;70(4):707-721.e7. doi: 10.1016/j.molcel.2018.04.008. Epub 2018 May 10. Mol Cell. 2018. PMID: 29754823 Free PMC article.
322 results