Lin CH - Search Results

1

Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.

Ho CW, Popat SD, Liu TW, Tsai KC, Ho MJ, Chen WH, Yang AS, Lin CH. Ho CW, et al. Among authors: lin ch. ACS Chem Biol. 2010 May 21;5(5):489-97. doi: 10.1021/cb100011u. ACS Chem Biol. 2010. PMID: 20187655

2

Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidase.

Chang CF, Ho CW, Wu CY, Chao TA, Wong CH, Lin CH. Chang CF, et al. Among authors: lin ch. Chem Biol. 2004 Sep;11(9):1301-6. doi: 10.1016/j.chembiol.2004.07.009. Chem Biol. 2004. PMID: 15380190

3

Discovery of different types of inhibition between the human and thermotoga maritima alpha-fucosidases by fuconojirimycin-based derivatives.

Ho CW, Lin YN, Chang CF, Li ST, Wu YT, Wu CY, Chang CF, Liu SW, Li YK, Lin CH. Ho CW, et al. Among authors: lin yn, lin ch. Biochemistry. 2006 May 9;45(18):5695-702. doi: 10.1021/bi052559n. Biochemistry. 2006. PMID: 16669613

4

Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors.

Shao YM, Yang WB, Peng HP, Hsu MF, Tsai KC, Kuo TH, Wang AH, Liang PH, Lin CH, Yang AS, Wong CH. Shao YM, et al. Among authors: lin ch. Chembiochem. 2007 Sep 24;8(14):1654-7. doi: 10.1002/cbic.200700254. Chembiochem. 2007. PMID: 17722121 Free PMC article.

5

Factor Xa active site substrate specificity with substrate phage display and computational molecular modeling.

Hsu HJ, Tsai KC, Sun YK, Chang HJ, Huang YJ, Yu HM, Lin CH, Mao SS, Yang AS. Hsu HJ, et al. Among authors: lin ch. J Biol Chem. 2008 May 2;283(18):12343-53. doi: 10.1074/jbc.M708843200. Epub 2008 Feb 22. J Biol Chem. 2008. PMID: 18296445 Free PMC article.

6

Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease.

Shao YM, Yang WB, Kuo TH, Tsai KC, Lin CH, Yang AS, Liang PH, Wong CH. Shao YM, et al. Among authors: lin ch. Bioorg Med Chem. 2008 Apr 15;16(8):4652-60. doi: 10.1016/j.bmc.2008.02.040. Epub 2008 Feb 15. Bioorg Med Chem. 2008. PMID: 18329272 Free PMC article.

7

Role for alpha-L-fucosidase in the control of Helicobacter pylori-infected gastric cancer cells.

Liu TW, Ho CW, Huang HH, Chang SM, Popat SD, Wang YT, Wu MS, Chen YJ, Lin CH. Liu TW, et al. Among authors: lin ch. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14581-6. doi: 10.1073/pnas.0903286106. Epub 2009 Aug 7. Proc Natl Acad Sci U S A. 2009. PMID: 19666478 Free PMC article.

8

Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism.

Chen YY, Ko TP, Chen WH, Lo LP, Lin CH, Wang AH. Chen YY, et al. Among authors: lin ch. J Struct Biol. 2010 Jan;169(1):25-35. doi: 10.1016/j.jsb.2009.08.006. Epub 2009 Aug 15. J Struct Biol. 2010. PMID: 19686854

9

Structural basis of alpha-fucosidase inhibition by iminocyclitols with K(i) values in the micro- to picomolar range.

Wu HJ, Ho CW, Ko TP, Popat SD, Lin CH, Wang AH. Wu HJ, et al. Among authors: lin ch. Angew Chem Int Ed Engl. 2010;49(2):337-40. doi: 10.1002/anie.200905597. Angew Chem Int Ed Engl. 2010. PMID: 19967696 No abstract available.

10

Structural and thermodynamic analyses of α-L-fucosidase inhibitors.

Lammerts van Bueren A, Popat SD, Lin CH, Davies GJ. Lammerts van Bueren A, et al. Among authors: lin ch. Chembiochem. 2010 Sep 24;11(14):1971-4. doi: 10.1002/cbic.201000339. Chembiochem. 2010. PMID: 20665773 No abstract available.

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